[광우병] 프리온 감염에서 나이에 따른 감수성 차이

건강과대안 — Wed, 08 Sep 2010 17:32:20 +0000

마우스 실험을 통해 프리온 감염에 있어서 나이(연령)에 따른 감수성의 차이를 연구한 논문입니다.

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Age-related alterations affect the susceptibility of mice to prion infection

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Dana Avrahami

^a^, and Ruth Gabizon ^,^a^,

^a Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel

Received 12 July 2009;

revised 10 December 2009;

accepted 21 December 2009.

Available online 31 December 2009.

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T09-4Y29SSG-3&_user=10&_coverDate=12%2F31%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1454112623&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ae4e0902e4a5403eb5748b5a012c9c99&searchtype=a

Introduction

Materials and methods: 2.1. Animal study; 2.2. Histology and immunohistochemistry; 2.3. Preparation of brain homogenates; 2.4. Immunoblotting; 2.5. Real-time PCR; 2.6. Statistical analysis

Results: 3.1. Extended incubation time of prion disease in mice infected at old age; 3.2. Milder neuropathology of prion disease in mice infected at older age; 3.3. Decreased accumulation of PrP^Sc in the brains and spleens of aged mice; 3.4. Elevated PrP^C protein levels in the brains of normal aged mice; 3.5. Spleens of aged and young naïve mice present comparable mRNA levels of tyrosine hydroxylase (TH); 3.6. The effect of age on the upregulation of disease-associated genes in response to prion infection

Discussion

Conflict of statement

References

건강과 대안 » Gene expression

[광우병] 프리온 감염에서 나이에 따른 감수성 차이