President Barack Obama asked the Commission to review the developing field of synthetic biology and identify appropriate ethical boundaries to maximize public benefits and minimize risks. The Commission approached this task through inclusive and deliberative engagement with a wide variety of sources, including scientists, engineers, faith-based and secular ethicists, and others who voiced, as expected, sometimes conflicting views on the science, ethics, and social issues surrounding synthetic biology. Through public meetings in Washington, D.C., Philadelphia, and Atlanta, the Commission created a forum for open dialogue to hear and assess competing claims about the science, ethics, and public policy relating to synthetic biology.