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	<title>건강과 대안 &#187; 라운드업</title>
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		<title>[GMO] 유전자 조작 식품, 당신의 건강을 심각하게 해칠 수 있다</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3776</link>
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		<pubDate>Sat, 02 Mar 2013 13:51:56 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[건강 유해성]]></category>
		<category><![CDATA[라운드업]]></category>
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		<category><![CDATA[유전자조작 식품]]></category>
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		<description><![CDATA[Warning: Food can seriously damage your healthMaarten RabaeyDe Morgen, 16 February 2013 (Original in Dutch)&#160;Translated into English by New Europe Translationshttp://gmoseralini.org/warning-food-can-seriously-damage-your-health/*The horsemeat scandal is just the tip of [...]]]></description>
				<content:encoded><![CDATA[<p><P><STRONG><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Warning: Food can seriously damage your health</SPAN></STRONG><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Maarten Rabaey</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">De Morgen, 16 February 2013 (Original in Dutch)&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Translated into English by New Europe Translations</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://gmoseralini.org/warning-food-can-seriously-damage-your-health/" target=_blank wrc_done="true">http://gmoseralini.org/warning-food-can-seriously-damage-your-health/</A><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">*The horsemeat scandal is just the tip of the iceberg, as consumers don&#8217;t know what&#8217;s in their food, regardless of packaging fraud.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">*More and more food contains residues of carcinogenic herbicides.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">*The industry has a strong hold on Europe&#8217;s food safety agency, holding back independent standards and inspections. </SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Two years ago, Danish farmer Ib Borup Pedersen thought an epidemic had broken out among his 450 pigs. Suddenly, his animals were suffering from chronic diarrhoea, eating less, or developing stomach ulcers, while some of his piglets were born with disabilities and his boars displayed fertility problems. Something always seemed to be the matter. Not just with the pigs, but with the profits of his farming company as well. Due to the increasing number of unhealthy animals, his sales plummeted, while the expenses for vets and drugs kept rising. Until he asked himself the crucial question: what if it was the feed?</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Pedersen followed his farmer&#8217;s intuition and exchanged the new feed for his old recipe. And what do you know – the health problems disappeared within two days. What was the difference? The feed that sickened the animals consisted of imported genetically modified (GMO) soy, whereas the old recipe consisted of soy without GMOs and fishmeal. Other farmers have since confirmed the findings, published by Pedersen on 13 April last year, in the Danish farming magazine Effektivt Landbrug.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Independent scientists were not surprised. They have increasingly warned against the GMO that Pedersen was using as feed, Roundup Ready (RR) soy, a crop genetically engineered to be resistant to Roundup. This is a weedkiller containing glyphosate, a toxin that kills all other plants without harming the crop.&nbsp; Both the glyphosate-resistant crop and the herbicide were developed by agricultural corporation Monsanto, which uses both products for its production of large scale GMO-monocultures in North and South America.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&nbsp;</P><br />
<P><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Birth defects</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Other corporations produce similar glyphosate herbicides, ignoring the distressed cry of several Argentine farmers who sued Monsanto after witnessing an increase of cancer and birth defects among their children, as a result of using glyphosate herbicides. An Argentine professor has previously shown that glyphosate produces birth defects in the embryos of frogs and chickens.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The experience of the Danish farmer raises the question of how harmful the glyphosate residues are that end up in our food – in pigs, cattle or horses through animal feed, in human bodies through our consumption of meat and milk. Or even directly, because GMO soy proteins are used as an emulsifier in numerous food preparations.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Aziz Aris and Samuel Leblanc from the University of Sherbrooke, Canada, demonstrated the transmission of the toxin via GMO crops to the human body in February 2011. In a study published in the Elsevier journal Reproductive Toxicology, they revealed the presence of toxic Roundup components, such as glyphosate, in the bloodstream of pregnant women and fetuses. “Considering the toxicity of these pollutants and the vulnerability of fetuses, further studies are needed,” they wrote. The same warning resounded elsewhere. In Berlin, between 0.5 and 2 nanograms of glyphosate per milliliter of urine were observed among townspeople who had never had any direct contact with the toxin.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Gilles-Eric Séralini and his team from the University of Caen, France, conducted similar experiments on rats. Their conclusions, published in August of last year, in the journal Food and Chemical Toxicology, were shocking: compared to a control group fed on a normal diet, rats on a diet containing 11 percent of RR corn, died two to three times as often and faster. Females were quicker to develop breast tumors; their hormone balance was upset. In males, the scientists observed 5.5 times more cases of vascular congestion and destruction of liver cells. But, more importantly, they developed four times as many tumors, up to 600 days earlier than the control group.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">After this study, the European Parliament quite logically asked the European Food Safety Authority (EFSA) for a critical analysis of all imported RR-GMO feed, and its consequences for the public health. However, the EFSA did not act. On the contrary, it attempted to discredit the statistical reliability of Séralini&#8217;s study. In the EFSA, glyphosate standards are &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;still determined by a scientific committee, the PPR or pesticides panel. Although its advice is not binding, the Commission tends to follow it without reflection. &#8220;The reason why the PPR panel&#8217;s judgments are so favourable towards the industry, is because members of the panel have ties to that industry,&#8221; says Nina Holland of Corporate Europe Observatory, an NGO that insists on greater transparency. &#8220;After a critical report by the Court of Auditors last year regarding conflicts of interest, their rules have become stricter, but the industry’s influence is still too big. The problem is that the agency employs few peop</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">le on a&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">permanent basis and that its panels need to rely on &#8216;volunteers&#8217;. The industry takes advantage of this fact by sending academics whom they support financially.&#8221;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">A telling example is the vice-president of the PPR panel, the Dutchman Theodorus Brock. He conducts research for the Alterra institute, operating under the aegis of Wageningen University. During the last five years, he has also worked as a consultant for Monsanto. His panel was among those to brush aside Séralini&#8217;s study and the Argentinean research on deformities as unreliable. &#8220;And that&#8217;s how it always goes,&#8221; sighs the Briton Claire Robinson, research director of Earth Open Source, an NGO advocating a sustainable food chain. &#8220;The problem is that the EFSA panels only take those studies seriously that are published by the industry or by universities funded by the industry. All research should be considered, and people need to accept the updating of knowledge.&#8221;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The industry&#8217;s wishes</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Last year, in collaboration with academics from the School of Medicine of London&#8217;s King College, Robinson published a peer-reviewed paper in a journal called Environmental &#038; Analytical Toxicology, which criticizes the admission of glyphosate and glyphosate-resistant crops. Robinson said: &#8220;The current EU-license for glyphosate dates from 2002 and is based on the Germans license of that time. It should normally have been re-evaluated last year. The European Parliament demanded tougher standards, but the Commission simply prolonged the current standards for another three years. There are, however, reasonable grounds to question the first admission that we analysed. There were certain birth defects, for instance, among the rats and rabbits that were tested, but these were presented inoffensively as ‘development variations’. On the other hand, we now have studies not only indicating the harmful effects of glyphosate but of other Roundup components as well. AMPA, for instance,&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">the&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">compound that is supposed to break down glyphosate in a natural environment, is harmful to human DNA. There are also indications that the commonly used side product, POEA, which facilitates the penetration of glyphosate in GMO crops, also increases its penetration in human cells.&#8221;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Robinson&#8217;s team also doubts the &#8216;acceptable daily intake&#8217; (ADI) for glyphosate. The Commission pegged it at 0.3 mg/kg, whereas initial animal testing would advise a minimum of 20 mg/kg.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">[Correction from Claire Robinson: The 20 mg/kg figure is not correct. Our paper concluded that based on the initial industry studies, the ADI should be 0.1 mg/ kg bw/d (bodyweight per day), one-third of the ADI suggested by the German authorities and subsequently adopted by the EU Commission. The ADI based on independent studies should be even lower: 0.025 mg/kg bw/d, twelve times lower than the ADI accepted by the Commission and currently in force.]</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Robinson said: &#8220;This also goes to show that the EFSA simply adapts the standards to the industry&#8217;s wishes. Lentils are a striking example. The residual standard for glyphosate was increased at Monsanto&#8217;s request&#8221; (from 0.1 mg/kg to 15mg/kg). The same more or less happened with the standards for animal fodder imported from Argentina.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The doses are increased because weeds are becoming more resistant to glyphosate herbicides. Herman van Bekkem, GMO campaign manager for Greenpeace, said: &#8220;That is because the industry either increased the concentration of its product or farmers started spraying more, with higher levels of residues ending up in the food chain.&#8221; Van Bekkem is worried because this year the EU is considering 19 GMO crops for cultivation in Europe.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&#8220;Thirteen of those are glyphosate-resistant. Once the farmers start cultivating these crops, there&#8217;s almost no way back. They&#8217;ll be trapped in a monopoly of package deals: GMO-seeds and weed killer are one and the same package. As consumers, we&#8217;d be far more exposed to glyphosate than we are now. If these crops are allowed, the use of glyphosate will increase by 800 percent.&#8221;</SPAN></P></p>
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		<title>[ GMO] 라운드업 제초제 공식적으로 발표된 것보다 독성 더 강해</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3774</link>
		<comments>http://www.chsc.or.kr/?post_type=reference&#038;p=3774#comments</comments>
		<pubDate>Sat, 02 Mar 2013 13:21:50 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[glyphosate]]></category>
		<category><![CDATA[POE-15 family]]></category>
		<category><![CDATA[polyethoxylated tallowamine]]></category>
		<category><![CDATA[글리포세이트]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[몬산토]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[유전자조작 옥수수]]></category>

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		<description><![CDATA[프랑스 칸대학의 Robin Mesnage, Benoit Bernay, Gilles-Eric Seralini팀이 지에라운드업 제초제의 주 성분인 글리포세이트계 제초제의 에톡시레이티드 보강제(adjuvants, POE-15 family (polyethoxylated tallowamine))의 인간 세포 독성 실험&#160;결과를 발표했다는 소식입니다.&#160;그 결과 글리포세이트 [...]]]></description>
				<content:encoded><![CDATA[<p><P>프랑스 칸대학의 <FONT color=#454545>Robin Mesnage, Benoit Bernay, Gilles-Eric Seralini팀이 <Toxicology>지에<BR>라운드업 제초제의 주 성분인 글리포세이트계 제초제의 <FONT color=#000000>에톡시레이티드 보강제(<FONT color=#454545>adjuvants, POE-15 family (polyethoxylated tallowamine))</FONT>의 인간 세포 </FONT>독성 실험&nbsp;</FONT>결과를 발표했다는 소식입니다.<BR>&nbsp;<BR>그 결과 글리포세이트 단독으로 사용된 제초제보다 보강제(<FONT color=#454545>adjuvants)를 사용한 경우에 독성이<BR></FONT>더 강한 것으로 나타났다고 합니다.&nbsp;<FONT color=#454545> </FONT><BR><BR>=============================================<BR><FONT color=#454545><STRONG>Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity<BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"></STRONG><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Toxicity, 2013 (in press)</SPAN></FONT><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://dx.doi.org/10.1016/j.tox.2012.09.006" target=_blank wrc_done="true">http://dx.doi.org/10.1016/j.tox.2012.09.006</A><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Abstract<BR></SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Pesticides are always used in formulations as mixtures of an active principle with adjuvants. Glyphosate, the active ingredient of the major pesticide in the world, is an herbicide supposed to be specific on plant metabolism. Its adjuvants are generally considered as inert diluents. Since side effects for all these compounds have been claimed, we studied potential active principles for toxicity on human cells for 9 glyphosate-based formulations. For this we detailed their compositions and toxicities, and as controls we used a major adjuvant (the polyethoxylated tallowamine POE-15), glyphosate alone, and a total formulation without glyphosate. This was performed after 24 h exposures on hepatic (HepG2), embryonic (HEK293) and placental (JEG3) cell lines. We measured mitochondrial activities, membrane degradations, and caspases 3/7 activities. The compositions in adjuvants were analyzed by mass spectrometry. Here we demonstrate that all formulations are more toxic than glyphosat</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">e, and&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">we&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">separated experimentally three groups of formulations differentially toxic according to their concentrations in ethoxylated adjuvants. Among them, POE-15 clearly appears to be the most toxic principle against human cells, even if others are not excluded. It begins to be active with negative dose-dependent effects on cellular respiration and membrane integrity between 1 and 3 ppm, at environmental/occupational doses. We demonstrate in addition that POE-15 induces necrosis when its first micellization process occurs, by contrast to glyphosate which is known to promote endocrine disrupting effects after entering cells. Altogether, these results challenge the establishment of guidance values such as the acceptable daily intake of glyphosate, when these are mostly based on a long term in vivo test of glyphosate alone. Since pesticides are always used with adjuvants that could change their toxicity, the necessity to assess their whole formulations as mixtures becomes obvious. This&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">challenges the concept of active principle of pesticides for non-target species.</SPAN><BR><BR><BR>==============================================<BR><BR>Roundup more toxic than officially declared &#8211; new study</P><br />
<P class=articleinfo><SPAN class=createdate>Thursday, 21 February 2013 21:31<BR>&nbsp;<BR><A href="http://gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14654:roundup-more-toxic-than-officially-declared-new-study">http://gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14654:roundup-more-toxic-than-officially-declared-new-study</A></SPAN></P><br />
<P class=buttonheading><STRONG><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The most widely used herbicide in the world contains compounds more toxic than declared &#8211; new research shows</SPAN></STRONG><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">CRIIGEN PRESS RELEASE</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Caen, France, Feb. 21st, 2013&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">In a new research(1) published in the highly ranked scientific journal Toxicology, Robin Mesnage, Benoit Bernay and Professor Gilles-Eric Seralini, from the University of Caen, France, have proven (from a study of nine Roundup-like herbicides) that the most toxic compound is not glyphosate, which is the substance the most assessed by regulatory authorities, but a compound that is not always listed on the label, called POE-15. Modern methods were applied at the cellular level (on three human cell lines), and mass spectrometry (studies on the nature of molecules). This allowed the researchers to identify and analyse the effects of these compounds.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Context: Glyphosate is supposed to be the &#8220;active ingredient&#8221; of Roundup, the most widely used herbicide in the world, and it is present in a large group of Roundup-like herbicides. It has been safety tested on mammals for the purposes of regulatory risk assessment. But the commercial formulations of these pesticides as they are sold and used contain added ingredients (adjuvants). These are often classified confidential and described as &#8220;inerts&#8221;. However, they help to stabilize the chemical compound glyphosate and help it to penetrate plants, in the manner of corrosive detergents. The formulated herbicides (including Roundup) can affect all living cells, especially human cells. This danger is overlooked because glyphosate and Roundup are treated as the same by industry and regulators in long-term studies. The supposed non-toxicity of glyphosate serves as a basis for the commercial release of Roundup. The health and environmental agencies and pesticide companies assess the lon</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">g-term&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">effects on mammals of glyphosate alone, and not the full formulation. The details of this regulatory assessment are jealously kept confidential by companies like Monsanto and health and environmental agencies.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Conclusion and consequences: This study demonstrates that all the glyphosate-based herbicides tested are more toxic than glyphosate alone, and explains why. Thus their regulatory assessments and the maximum residue levels authorized in the environment, food, and feed, are erroneous. A drink (such as tap water contaminated by Roundup residues) or a food made with a Roundup tolerant GMO (like a transgenic soya or corn) were already demonstrated as toxic in the recent rat feeding study (2) from Prof. Séralini team. The researchers have also published responses to critics of the study (3).&nbsp; This new research explains and confirms the scientific results of the rat feeding study.&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Overall, it is a great matter of concern for public health. First, all authorizations of Roundup-type herbicides have to be questioned urgently. Second, the regulatory assessment rules have to be fully revised. They should be analyzed in a transparent and contradictory manner by the scientific community. Agencies that give opinions to government authorities, in common with the pesticide companies generally conclude safety. The agencies’ opinions are wrong because they are made on the basis of lax assessments and much of the industry data is kept confidential, meaning that a full and transparent assessment cannot be carried out. These assessments are therefore neither neutral nor independent. They should as a first step make public on the Internet all the data that underpin the commercial release and positive opinions on the use of Roundup and similar products. The industry toxicological data must be legally made public.&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Adjuvants of the POE-15 family (polyethoxylated tallowamine) have now been revealed as actively toxic to human cells, and must be regulated as such. The complete formulations must be tested in long-term toxicity studies and the results taken into account in regulatory assessments. The regulatory authorisation process for pesticides released into the environment and sold in stores must urgently be revised. Moreover, since the toxic confidential adjuvants are in general use in pesticide formulations, we fear according to these discoveries that the toxicity of all pesticides has been very significantly underestimated.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">This study was conducted in the University of Caen with the structural support of CRIIGEN in the European Network of Scientists for Social and Environmental Responsibility (ENSSER www.ensser.org <</SPAN><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://www.ensser.org/" target=_blank wrc_done="true">http://www.ensser.org</A><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">> ).</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Contact:&nbsp;</SPAN><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="mailto:%20%3Cscript%20language='JavaScript'%20type='text/javascript'%3E%20%3C!--%20var%20prefix%20=%20'mailto:';%20var%20suffix%20=%20'';%20var%20attribs%20=%20'';%20var%20path%20=%20'hr'%20+%20'ef'%20+%20'=';%20var%20addy31547%20=%20'criigen'%20+%20'@';%20addy31547%20=%20addy31547%20+%20'unicaen'%20+%20'.'%20+%20'fr';%20document.write(%20'%3Ca%20'%20+%20path%20+%20'\''%20+%20prefix%20+%20addy31547%20+%20suffix%20+%20'\''%20+%20attribs%20+%20'%3E'%20);%20document.write(%20addy31547%20);%20document.write(%20'%3C\/a%3E'%20);%20//--%3E%20%3C/script%3E%3Cscript%20language='JavaScript'%20type='text/javascript'%3E%20%3C!--%20document.write(%20'%3Cspan%20style=\'display:%20none;\'%3E'%20);%20//--%3E%20%3C/script%3EThis%20e-mail%20address%20is%20being%20protected%20from%20spambots.%20You%20need%20JavaScript%20enabled%20to%20view%20it%20%3Cscript%20language='JavaScript'%20type='text/javascript'%3E%20%3C!--%20document.write(%20'%3C/'%20);%20document.write(%20'span%3E'%20);%20//--%3E%20%3C/script%3E" ymailto="mailto:&#10; <script language='JavaScript' type='text/javascript'>&#10; <!--&#10; var prefix = 'mailto:';&#10; var suffix = '';&#10; var attribs = '';&#10; var path = 'hr' + 'ef' + '=';&#10; var addy13682 = 'criigen' + '@';&#10; addy13682 = addy13682 + 'unicaen' + '.' + 'fr';&#10; document.write( '<a ' + path + '\'' + prefix + addy13682 + suffix + '\'' + attribs + '>&#8216; );&#10; document.write( addy13682 );&#10; document.write( &#8216;<\/a>&#8216; );&#10; //&#8211;>&#10; </script><script language='JavaScript' type='text/javascript'>&#10; <!--&#10; document.write( '<span style=\'display: none;\'>' );&#10; //-->&#10; </script>This e-mail address is being protected from spambots. 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 //--></SCRIPT> </SPAN></A><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">; phone +33 (0)231565684 (France). www.criigen.org <</SPAN><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://www.criigen.org/" target=_blank wrc_done="true">http://www.criigen.org</A><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&nbsp;</SPAN><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">>&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">----</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Notes:</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">(1) Mesnage R., Bernay B., Seralini G-E. (2013, in press). Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity. Toxicology&nbsp;</SPAN><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://dx.doi.org/10.1016/j.tox.2012.09.006" target=_blank wrc_done="true">http://dx.doi.org/10.1016/j.tox.2012.09.006</A><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">(2)&nbsp; Seralini G. E., et al. (2012). Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food and Chemical Toxicology 50 (11): 4221-4231.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">(3)&nbsp; Seralini G. E., et al. (2013). Answers to critics: Why there is a long term toxicity due to NK603 Roundup-tolerant genetically modified maize and to a Roundup herbicide. Food and Chemical Toxicology</SPAN></P></p>
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		<title>[GMO] Jack A. Heinemann 교수의 세라리니 교수 연구 평가</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3771</link>
		<comments>http://www.chsc.or.kr/?post_type=reference&#038;p=3771#comments</comments>
		<pubDate>Sat, 02 Mar 2013 12:54:19 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[glyphosate]]></category>
		<category><![CDATA[Jack A. Heinemann]]></category>
		<category><![CDATA[글리포세이트]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[몬산토]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[유전자조작 옥수수]]></category>

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		<description><![CDATA[Seralini study a valuable contribution to the scientific literature Monday, 11 February 2013 12:53 http://gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14635:seralini-study-a-valuable-contribution-to-the-scientific-literature NOTE: This carefully considered letter from Prof Jack Heinemann has just been published [...]]]></description>
				<content:encoded><![CDATA[<p><P>Seralini study a valuable contribution to the scientific literature</P><br />
<P class=articleinfo><SPAN class=createdate>Monday, 11 February 2013 12:53 <BR><A href="http://gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14635:seralini-study-a-valuable-contribution-to-the-scientific-literature">http://gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14635:seralini-study-a-valuable-contribution-to-the-scientific-literature</A><BR><BR></P><br />
<P><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><STRONG>NOTE:</STRONG> This carefully considered letter from Prof Jack Heinemann has just been published in Food and Chemical Toxicology, the journal that published Seralini&#8217;s research back in September.&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Seralini&#8217;s research found serious health problems in rats that had been fed a Monsanto maize genetically engineered to be resistant to the company&#8217;s herbicide Roundup, as well as in rats just fed low doses of the herbicide itself. In both cases the rats fed with the GM maize and/or minute amounts of the herbicide in water were several times more likely to develop lethal tumours and suffer severe liver and kidney damage when compared to the controls.&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">On its publication industry-linked scientists and lobbyists launched a campaign to get the Seralini study retracted. How the campaign was orchestrated is described here:</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><A id=yui_3_7_2_1_1360588913213_4393 style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://www.spinwatch.org/-articles-by-category-mainmenu-8/46-gm-industry/5546" target=_blank><SPAN class=yshortcuts id=lw_1360589469_0>http://www.spinwatch.org/-articles-by-category-mainmenu-8/46-gm-industry/5546</SPAN></A><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Letters to Food and Chemical Toxicology have been a big part of the retraction campaign, but this letter sets out clearly some of the reasons why this campaign has so far failed. For more information about the study and the responses see: &nbsp;</SPAN><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://gmoseralini.org/" target=_blank><SPAN class=yshortcuts id=lw_1360589469_1>http://gmoseralini.org/</SPAN></A><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">And please support the petition calling for better testing of GM foods:</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://www.avaaz.org/en/petition/Freeze_GM_food_approvals_now/" target=_blank><SPAN class=yshortcuts id=lw_1360589469_2>http://www.avaaz.org/en/petition/Freeze_GM_food_approvals_now/</SPAN></A><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&#8212;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&#8212;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><STRONG><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Food and Chemical Toxicology 53 (2013) 427</SPAN></STRONG><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><A style="COLOR: rgb(40,98,197); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://www.ask-force.org/web/Seralini/Heinemann-Letter-to-Editor-FCT-20121107.pdf" target=_blank><SPAN class=yshortcuts id=lw_1360589469_3>http://www.ask-force.org/web/Seralini/Heinemann-Letter-to-Editor-FCT-20121107.pdf</SPAN></A><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Dear Editor</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">I have carefully read the [Seralini et all] paper entitled &#8220;Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize&#8221;. I am very familiar with historical publications on this topic.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">A number of criticisms of this paper have appeared in the media. They appeared shockingly quickly which caused me concern because I find it takes more time to properly and thoroughly read a scientific paper of this complexity. Most criticisms were of a general nature and without substance worthy of entering the scientific debate. Some criticisms were specific, referring to the type of rat used, the kind of statistical analysis, and the interpretation of the response to increasing concentrations of the agrichemicals, Roundup, or genetically modified plant ingredient.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">I performed a quick review of papers on rat feeding studies using genetically modified feed components also published in this same journal. In addition to the paper by Seralini et al., I found seven studies between 2004 and now all published in Food and Chemical Toxicology in which Sprague–Dawley rats were fed diets supplemented with material from GM plants. All of these papers were published by those companies who developed the GM plant used in the study. One paper was from Monsanto, and the others from DuPont/Pioneer. None of the papers extended beyond 90 days.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">These studies used approximately the same number of rats as the study by Seralini et al. All of them used the same kind of rat as the Seralini et al. study. The 2004 study by Hammond used marginally more rats in the relevant control group, but was in my opinion less powerful statistically because of the inclusion of &#8216;reference&#8217; control lines that were not fed on the near-isogenic non-GM diet. The power gained by the additional rats (20/sex vs. 10/sex) was offset by the noise introduced by irrelevant variables.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The statistics used in these other studies passed anonymous peer-review. Aside from that, there is no other peer-reviewed evidence that these statistical approaches are either uniquely appropriate or validated for their use in this kind of study. On those fronts, I find Seralini et al.&#8217;s statistical analysis equally valid.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">I would encourage both the scientific community and the regulatory community to engage in an exercise of validation of statistical analyses if this remains an issue of contention.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Where the Seralini et al. study has no peer in this group of papers is in its duration. No number of 90 day feeding studies can refute the findings of a long term study when the effects are largely those that appear after 90 days.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Some critics have attempted to disparage the most recent findings by drawing doubt on the nature of the response, pointing out that the severity of the effect did not uniformly increase with dosage. I am aware of a number of toxicological studies that report similar phenomena. For example, Welshons et al. (2003) said in their article in Health Perspectives: &#8220;Furthermore, receptor-mediated responses can first increase and then decrease as dose increases, contradicting the assumption that dose–response relationships are monotonic.&#8221;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The effect fits perfectly well with receptor-mediated or saturated effects and within the hypotheses presented by Seralini et al. While there is always room for more science on any topic, in my opinion the Seralini et al. study stands shoulder to shoulder with the best of those published by others on this same issue. Importantly, it explores hypotheses that industry-based authors largely did not and therefore these earlier studies are in no way evidence against the most recent findings. The proper pathway forward is for any uncertainty in the findings to be put to rest through: the establishment of a consensus protocol developed through a transparent and openly peer-reviewed methodology; definitive study using this protocol to be conducted by industry-independent scientists of appropriate qualifications, such as Seralini et al., with reasonable access for observation by those nominated by the industry and regulatory communities.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">In the meantime, it is my view that the recent study is a valuable contribution to the scientific literature, debate and process of evaluating technologies. I trust your journal to publish quality science and you have vindicated my trust.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Jack A. Heinemann</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Centre for Integrated Research in Biosafety, School of Biologial Sciences, University of Canterbury, Christchurch, New Zealand&nbsp;</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Reference</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Welshons, W.V., Thayer, K.A., Judy, B.M., Taylor, J.A., Curran, E.M., vom Saal, F.S., 2003. Large effects from small exposures. I. Mechanisms for endocrinedisrupting chemicals with estrogenic activity. Environ. Health Perspect. 111, 994–1006.</SPAN><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="COLOR: rgb(69,69,69); LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Available online 6 November 2012 0278-6915/$</SPAN></P><br />
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		<title>몬산토, ‘죽음의 상인’인가, 인류를 해방할 ‘구세주’인가?</title>
		<link>http://www.chsc.or.kr/?post_type=paper&#038;p=4735</link>
		<comments>http://www.chsc.or.kr/?post_type=paper&#038;p=4735#comments</comments>
		<pubDate>Thu, 14 Feb 2013 01:32:16 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[건강 영향]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[몬산토]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[장기독성연구]]></category>
		<category><![CDATA[종양]]></category>

		<guid isPermaLink="false">http://www.chsc.or.kr/?post_type=paper&#038;p=4735</guid>
		<description><![CDATA[지난 2012년 GMO관련 장기독성 연구를 진행한 프랑스 칸 대학 세라리니 교수 연구팀의 연구결과를 둘러싸고 세계적인 논쟁이 일어난 바 있다.  박상표 운영위원이 지난 오픈세미나 발제에 이어, 이를 정리하여 &#60;시민과학&#62;에 [...]]]></description>
				<content:encoded><![CDATA[<p><span style="font-family: Gulim; font-size: small; line-height: 20px; background-color: #ffffff;">지난 2012년 GMO관련 장기독성 연구를 진행한 프랑스 칸 대학 세라리니 교수 연구팀의 연구결과를 둘러싸고 세계적인 논쟁이 일어난 바 있다. </span></p>
<div><span style="background-color: #ffffff; font-family: Gulim; font-size: small; line-height: 20px;">박상표 운영위원이 지난 오픈세미나 발제에 이어, 이를 정리하여 &lt;시민과학&gt;에 기고하면서 동시에 건강과대안 이슈페이퍼로도 발간하게 되었다. </span></div>
<div><span style="font-family: Gulim; font-size: small;"><span style="line-height: 1.6;"> </span></span></div>
<div><span style="font-family: Gulim; font-size: small;"><span style="line-height: 1.6;">프랑스 세라리니 교수팀이 진행한 연구인, 몬산토 사의 라운드업 제초제와 그 제초제에 내성을 가진 GM 옥수수(NK603)에 대한 2년 동안의 장기 독성 연구결과. 그리고 이에 대한 GM찬성론자들의 반박, 이를 다시 재반박하는 세라리니 교수팀의 논리를 일목요연하게 정리하였기에 일독을 권한다. </span></span></div>
<div><span style="font-family: Gulim; font-size: small;"><span style="line-height: 1.6;"> </span></span></div>
<div><span style="font-family: Gulim; font-size: small;"><span style="line-height: 1.6;">============================================</span></span></div>
<div><span style="font-family: Gulim; font-size: small;"><span style="line-height: 1.6;"> </span></span></div>
<div><span style="font-family: Gulim; font-size: small;"><span style="line-height: 1.6;"><b>목차</b></span></span></div>
<div>
<p class="바탕글"><span lang="EN-US"><span style="font-family: Gulim; font-size: small;"><b>1. 프랑스 세라리니 교수팀의 연구 결과</b></span></span></p>
<p class="바탕글"><!--[if !supportEmptyParas]--><span style="font-family: Gulim; font-size: small;"><b> <!--[endif]--><span style="line-height: 1.6;">2. 세라리니 교수팀의 장기 독성 연구 배경</span></b></span></p>
<p class="바탕글"><!--[if !supportEmptyParas]--><span style="font-family: Gulim; font-size: small;"><b> <!--[endif]--><span style="line-height: 1.6;">3. 세라리니 교수 연구팀의 연구결과에 대한 산업계 및 과학계의 반응</span></b></span></p>
<p class="바탕글"><span style="line-height: 1.6;"><span style="font-family: Gulim; font-size: small;"><b>-비판과 반박</b></span></span></p>
<p class="바탕글"><span lang="EN-US"><span style="font-family: Gulim; font-size: small;"><b>4. 이제는 GM 곡물의 장기 독성에 대한 과학적 규명에 나서야 할 때</b></span></span></p>
</div>
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		<title>[GMO] 기업 쥐들의 구린내 : 세라리니 공격자들 드러나</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3635</link>
		<comments>http://www.chsc.or.kr/?post_type=reference&#038;p=3635#comments</comments>
		<pubDate>Wed, 26 Dec 2012 19:47:55 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[glyphosate]]></category>
		<category><![CDATA[글리포세이트]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[몬산토]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[유전자조작 옥수수]]></category>
		<category><![CDATA[청부 과학자]]></category>

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		<description><![CDATA[기업 쥐들의&#160;구린내 : 세라리니 공격자들 드러나GMwatch의 Jonathan Matthews가 몬산토사의 유전자조작 옥수수와 라운드업 제초제의 장기 독성 연구결과를 발표한 세라리니 교수팀을 공격하고 있는 생명공학산업계와&#160;연관된 과학자들과 로비스트들을 추적하여 비판한 글입니다.생명공학산업계와&#160;연관된 과학자들과 [...]]]></description>
				<content:encoded><![CDATA[<p><FONT color=#454545 size=2><STRONG>기업 쥐들의&nbsp;구린내 : 세라리니 공격자들 드러나<BR><BR>GMwatch의 Jonathan Matthews가 몬산토사의 유전자조작 옥수수와 라운드업 제초제의 장기 독성 연구결과를 발표한 세라리니 교수팀을 공격하고 있는 생명공학산업계와&nbsp;연관된 과학자들과 로비스트들을 추적하여 비판한 글입니다.<BR><BR>생명공학산업계와&nbsp;연관된 과학자들과 로비스트들은 세라리니 교수팀의 논문을 학술지에서 철회하라는 온라인 서명운동을 주도하고 있으며, 세라리니 교수팀의 실험 데이터를&nbsp;입수하기 위해 데이터를 공개하라고 요구하고 있습니다.(참고로 EFSA가 몬산토사의 유전자조작 옥수수의 안전성을 평가하는데 사용했던 데이터는 젼혀 공개되지 않았습니다.)<BR><BR>Science Media Center(사이언스미디어센터; SMC)가 세라리니 교수팀의 논문을 공격하는 선봉장 역할을 했는데요&#8230; SMC는 과학자들의 견해와 정보를 언론과 일반 기자들에게 신속하고 정확하게 전달하기 위한 목적으로 2002년 영국에서 처음 설립되었는데&#8230; 현재&nbsp;호주, 뉴질랜드, 캐나다, 일본 등에도 설립되어 있으며, 우리나라는 지난 2004년 한국과학기자협회 산하에 미디어센터로 설립되었으나 2006년 이후 활동이 중단된 상태입니다.<BR><BR>SMC는 지난 2011년 3월 일본 후쿠시마 원전 사고 당시에도 원전 옹호론자들의 입장을 널리 퍼트린 것으로 악명이 높습니다.<BR><BR>지난 2005년 5월 황우석 전 서울대교수가 체세포복제 배아줄기세포를 만드는데 성공했다는 <사이언스>지 인터넷판 논문 게재 후에 기자회견을 한 곳도 바로 런던 소재 SMC였습니다.(MBC PD수첩을 통하여 황우석 교수팀의 연구부정행위가 폭로되었는데, 이명박 정부 들어서 김재철 사장이 취임한 이후 MBC PD수첩의 권력감시 기능이 약화되어 대통령 선거를 앞둔&nbsp;굉장히 중요한 시기에 아주 오랜 기간 동안 PD수첩 방송 자체가 결방되는 불행한 사태가 발생한 바 있습니다)<BR><BR>SMC는 세라리니 박사팀의 논문이 발표되자 마자 기다렸다는 듯이 몬산토 등 생명공학산업계를 옹호하는 과학자들과 로비스트들의 치밀하게 준비된 어록(quotes)들을 쏟아내기 시작했습니다. 미국 일리노이대학교 농업소비자환경대학 Bruce M. Chassy 교수의 비방 어록도 SMC가 만들어낸 작품 중의 하나였습니다.<BR></STRONG><BR><STRONG>Bruce M. Chassy는 <Economy Times>에 사설을 기고하여 </STRONG><STRONG><FONT color=#000000>GM종자가 일반적인 종자들에 비해서 훨씬 비싼데 과연 인도와 같은 개발도상국에게 GM작물을 재배하는 것이 적합하냐는&nbsp;의문을 제기하는데 대해&#8230; GM종자를 사용할 경우 생산량은 늘어나고 농약사용량은 줄어들기 때문에 &#8220;GM종자들이 엄청나게 비싼 것은 아니고 궁극적으로는 농부들에게 이익이 된다&#8221;는 거짓 주장을&nbsp;한 바 있습니다.(GM종자들은 몬산토, 카길, 다우케미칼 같은 기업들에게 이익이 됩니다.)<BR></FONT><BR>또한 Bruce M. Chassy는&nbsp;<Economy Times> 사설에서 </STRONG><FONT color=#000000><STRONG>GM식량이 건강에 해롭다는 사실에 대해서도 부정한 바 있습니다. 그는 &nbsp;“이런 의견은 정말 잘못된 생각이다. GM식량이 일반식량보다 더 영양이 풍부하고 유익하다는 것이 맞는 말이다. 전 세계 식량의 약 70%가 GM이며, 사람들은 GM식량이 아닌 비위생적인 유기농 식량을 통해서 병이 드는 것이다.”는 궤변을 늘어 놓은 바 있습니다.<BR></STRONG>(<STRONG><FONT color=#454545>Bruce M. Chassy는 몬산토의 치어리더 역할을 충실히 수행하고 있습니다)<BR></FONT></STRONG><BR><STRONG>세라리니 박사팀의 논문에 적개심을 보이며 공격한 또 하나의 핵심 축은 미국의 경제지 <포브스(<FONT color=#454545>Forbes)>였습니다. <포브스>는 세라리니 교수팀의 논문이 발표된 지 10일 이내에 연구결과와 연구진을 공격하는&nbsp;6개 이상의 비방 기사를 쏟아냈습니다. 처음 2개의&nbsp; <포브스> 기사는 Science Media Center(사이언스미디어센터)가 만들어낸 내용을 인용하였지만, 세라리니 교수를 좀 더 악의적으로 비방하는 데 역점을 두었습니다.</FONT></STRONG><BR></FONT><BR><STRONG>이러한 공격은 유전자 조작 감자의 위해성 문제를 제기했던 Arpad Pusztai 박사, 유전자조작 옥수수의 경작과 재배가 금지된 멕시코의 옥수수에 GM 유전자가 검출되었다는 사실을 학계에 보고한 David Quist와 Ignacio Chapela 박사를 공격했던 방식과 유사합니다.</STRONG>&nbsp;<BR><BR><STRONG>그리고 바로 그 배후엔 유전자조작 산업계의 로비 그룹인&nbsp; AgBioWorld의 과학자 CS Prakash가 있다는 사실이 드러났습니다. CS Prakash는 지난 2006년 인도에서 유전자조작 면화를 먹은 염소와 양이 사망하는 사건이 발생했을 때도 생명공학 업계를 옹호한 바 있습니다.</STRONG><BR><BR><STRONG>농업생명공학계를 옹호하는 청부과학자들에 대한 자세한 내용은 아래 원문을 참조하시기 바랍니다.</STRONG><BR><BR><BR><br />
<H2 class=contentheading>Smelling a corporate rat: Seralini attackers exposed</H2><br />
<P class=articleinfo><SPAN class=createdate><FONT color=#000000><STRONG>Thursday, 13 December 2012 11:32 </STRONG></FONT></SPAN></P><br />
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<P><STRONG><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The following article by Jonathan Matthews of GMWatch was called &#8220;the definitive analysis of the Séralini affair&#8221; by John Vidal, environment editor of The Guardian, on Twitter.<BR>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<BR></SPAN><BR>Smelling a corporate rat<BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"></STRONG></FONT><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Jonathan Matthews<BR>Spinwatch</SPAN><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">, 12 December 2012<BR></SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Article/pdf with links to sources: </SPAN><A style="FONT-SIZE: 13px; COLOR: #2862c5; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif; TEXT-DECORATION: underline; outline: 0px" href="http://bit.ly/TOZ3Fo" target=_blank>http://bit.ly/TOZ3Fo</A><BR><A href="http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14514:smelling-a-corporate-rat-seralini-attackers-exposed">http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14514:smelling-a-corporate-rat-seralini-attackers-exposed</A><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><STRONG><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">A new study suggesting a Monsanto GM maize and the company&#8217;s Roundup herbicide may pose serious health risks has been widely attacked, not just by scientists and commentators but also by scientific bodies and regulators. This article by Jonathan Matthews of GMWatch looks at the role of industry-linked scientists and lobbyists in a campaign aimed at getting the paper ret</SPAN><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">racted. </SPAN>Spinwatch also plans to publish a separate piece looking at some of the study&#8217;s European critics, including science academies and the European Food Safety Authority<EM>.</EM></SPAN></STRONG><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">At the end of November Reuters ran the headline Science Journal Urged to Retract Monsanto GM Study and New Scientist also reported the growing pressure for retraction. These articles marked the latest stage in a campaign that kicked off the moment the study was published in mid-September, when researchers led by Prof. Gilles-Eric Seralini at the University of Caen in France announced their findings of serious health problems in rats that had been fed a Monsanto maize genetically engineered to be resistant to the company&#8217;s herbicide Roundup, as well as in rats just fed low doses of the herbicide itself. In both cases the rats fed with the GM maize and/or minute amounts of the herbicide in water were several times more likely to develop lethal tumours and suffer severe liver and kidney damage when compared to the controls.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Science Media Centre spearheads the attack</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Although the publication of the results of the long-term feeding trial in Food and Chemical Toxicology made front page news in France, it got a very different reception in the English-speaking world. This was thanks to the rapid rebuttal efforts of the London-based Science Media Centre (SMC), which almost as soon as the study was published began spoon-feeding journalists with ready-made quotes from scientists savaging the study.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The SMC&#8217;s director Fiona Fox was subsequently reported as saying that she took pride in the fact that the SMC&#8217;s &#8220;emphatic thumbs down had largely been acknowledged throughout UK newsrooms: apart from the Mail, only the Daily Telegraph and the Financial Times covered the story in their print editions – and both used quotes supplied by the Science Media Centre.” She added that several television news programmes had also rejected the story after reading the quotes</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The SMC&#8217;s quotes were pumped out internationally via its clones, like the Australian Science Media Centre, with like-minded local experts layered on the top. The quotes were also circulated to the media by Monsanto and other GM lobby groups. As a result, the quotes ended up in a lot of media coverage worldwide. One even popped up in the New York Times along with the scathing comments of Bruce M. Chassy, professor emeritus of food science at the University of Illinois.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Retraction campaign kicks in</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Another key player in whipping up hostility to the paper was the American business magazine Forbes. In the ten days following the study&#8217;s release, Forbes published no less than six separate attack pieces targeting not just the research but also the researchers. The first two pieces drew extensively on the quotes from the Science Media Centre and ran with them, but the Forbes piece that grabbed the most attention, particularly on social media, was one that kicked off with a headline that labelled the paper a fraud. The article went on to accuse Prof. Seralini not just of &#8220;gross scientific misconduct&#8221; but also of having &#8220;a long and sordid history&#8221; of &#8220;activism&#8221;. The article concluded by bluntly telling the editors of Food and Chemical Toxicology that the only &#8220;honorable course of action for the journal would be to retract the paper immediately&#8221;.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The retraction campaign was by then well under way. An online petition was up and running, demanding in the name of &#8220;the scientific community&#8221; that Seralini hand over all his raw data. The petition was aggressively promoted via social media, often with the implication that the researchers had something to hide. The assertion that the study was &#8220;fraudulent&#8221; obviously played well into this campaign, which culminated in the Reuters and New Scientist pieces reporting the retraction calls. Both these articles reported on the petition, as well as containing lacerating comments from two UK scientists – comments once again provided by the Science Media Centre.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">One of the published comments – from Prof. Maurice Moloney – said it was &#8220;appalling&#8221; that such a study should ever have been published in a respected journal. And a researcher from the UK&#8217;s John Innes Centre demanded to know whether it was not &#8220;time for Food and Chemical Toxicology to retract the manuscript?&#8221; The only other scientist quoted claimed the publication of the paper was more than just &#8220;a dangerous case of failure of the peer-review system.&#8221; It represented a threat to not just the credibility of the journal but &#8220;the scientific method overall&#8221;. This apocalyptic claim was backed up by the news that hundreds of outraged scientists had signed the online petition. </SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Who&#8217;s behind the retraction petition?</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Writing in The Guardian at the end of September, John Vidal described the attacks already raining down on Seralini and his team as &#8220;a triumph for the scientific and corporate establishment which has used similar tactics to crush other scientists&#8221;. These included, Vidal said, &#8220;Arpad Pusztai of the Rowett Institute in Scotland, who was sacked after his research suggested GM potatoes damaged the stomach lining and immune system of rats, and David Quist and Ignacio Chapela&#8221;, who studied the flow of genes from illegally planted GM maize to Mexican indigenous maize.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The vociferous attacks on Quist and Chapela resulted in the apparent retraction of their paper by the journal Nature, even though such a move was not supported by the majority of its reviewers and subsequent research confirmed the paper’s main finding. But, as the French journalist Benjamin Sourice has pointed out, the simplest way to definitively discredit a study and nullify its impact is to pressurise the journal that published it to retract it from its list of publications.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">In the case of Quist and Chapela, an investigation that I undertook with the journalist and author Andy Rowell of Spinwatch revealed how the campaign of retraction had been carefully orchestrated from the start by Monsanto&#8217;s PR people. It used proxies to whip up feeling against the lead author by branding Dr Chapela an &#8220;activist&#8221; rather than a scientist and by maintaining his findings were bogus and arrived at through collusion with environmental NGOs. Our research, which was widely reported in both print and broadcast media, suggested that at the heart of that retraction campaign sat Monsanto&#8217;s former chief internet strategist and director of corporate communications. Jay Byrne had gone on to found his own internet PR company v-Fluence, based like Monsanto in the corporation&#8217;s home town of St Louis.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Although Byrne appeared to be the campaign&#8217;s chief architect, its principal conduit was the lobby group AgBioWorld, overseen by the GM scientist CS Prakash.&nbsp; The &#8220;ipetition&#8221; on Seralini contains no information as to who sponsored it, but its first signatory is CS Prakash. Prakash also seems to have set up an earlier more primitive version of the petition, which clearly identifies him as its sponsor.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Some time after GMWatch flagged up the likely role of Prakash and AgBioWorld in the ipetition, the organisation acknowledged its authorship in a press release which asserted that &#8220;the petitioning scientists are calling on the publishing journal editors to retract the Seralini study&#8221; if he failed to give in to their demand that he hand over all his data.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The AgBioWorld press release contained a quote by Bruce Chassy, who was also the first signatory of the earlier Seralini petition. Chassy was also the co-author of the Forbes piece accusing Seralini of fraud.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The article&#8217;s other author was Henry Miller, a darling of the rightwing press who operates out of the Hoover Institution, among other industry backed lobby groups. Miller, like Chassy, has long been associated with Prakash&#8217;s AgBioWorld. Miller recently co-authored another vitriolic piece on GM for Forbes, denouncing the &#8220;fear profiteers&#8221; of the anti-GM &#8220;protest industry&#8221;. Miller&#8217;s co-author on that occasion was none other than former Monsanto PR boss Jay Byrne of v-Fluence. Tellingly, Michael Pollan, the renowned New York Times food writer and professor of journalism at the UC Berkeley Graduate School of Journalism, described the piece by Byrne and Miller as a breathtaking example of &#8220;the Big Lie&#8221;.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Byrne hasn&#8217;t published any media pieces on Seralini. But it is apparent from Byrne&#8217;s Twitter account that he was almost solely preoccupied with discrediting the Seralini study from the day of its publication for about the next month. Byrne describes himself on Twitter as v-Fluence CEO and&nbsp; as &#8220;Contributing author, Let Them Eat Precaution&#8221;, a book on GM edited by Jon Entine. Entine, as it happens, is the author of probably more articles to date attacking Seralini than any other commentator.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Agribiz apologist</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Entine&#8217;s book emerged out of an American Enterprise Institute conference overseen by Entine at which Byrne was an invited speaker. And Byrne&#8217;s v-Fluence turns up again in company with Entine at another AEI conference he oversaw – this one attacking corporate social responsibility (CSR). According to Business Ethics: &#8220;A second AEI conference featured AEI fellow Jon Entine – a long-time critic of SRI [socially responsible investing] – and Sarah Fuhrmann of v-Fluence Interactive Public Relations. Several v-Fluence employees are ex-public affairs staffers for Monsanto – where they honed skills fighting CSR initiatives that targeted genetically modified foods.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Entine hasn&#8217;t just worked with Byrne and v-Fluence, but has also done paid work for Byrne&#8217;s company. In a piece about Entine by the food and farming commentator Tom Philpott, The Making of an Agribusiness Apologist, Entine denies being a hired gun for Syngenta in his work defending pesticides and downplays the fact that his company (ESG MediaMetrics) lists Monsanto as a client. This is how he explains it: &#8220;Nine years ago, I did a $2000 research project for v-Fluence, a social media company formed by former Monsanto executives. That&#8217;s the entirety of my Monsanto relationship.&#8221; Presumably Entine lists Monsanto and not Jay Byrne&#8217;s firm as his company&#8217;s paymaster because he recognises that what he does for v-Fluence he&#8217;s really doing for Monsanto.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Entine&#8217;s first attack on Seralini came out on Forbes within 24 hours of the paper&#8217;s publication. His second piece a few days later contained further attacks, not just on Seralini, whom he accused of steadfastly refusing to share his raw data, but on almost anyone who attempted to defend the study.&nbsp; Entine also published a third more recent article which focuses particularly on letters to Food and Chemical Toxicology requesting Seralini&#8217;s paper be retracted. In this he notes, &#8220;More than two dozen scientists from around the world co-signed a stinging rebuke of the Seralini study, concluding: &#8216;We appeal to you to subject the paper to rigorous re-review by appropriate experts and promptly retract it if it fails to meet widely held scientific standards of design and analysis, as we believe it fails to do.&#8217;&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The letter Entine is referring to was signed by, among others, CS Prakash, Henry Miller and Bruce Chassy. Several of the other signatories also have connections to AgBioWorld. Entine&#8217;s book on GM, incidentally, also has contributions from CS Prakash and his AgBioWorld co-founder, Greg Conko of the Competitive Enterprise Institute.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Cancer-prone rat</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Another signatory of this joint letter to Food and Chemical Toxicology is Prof. Anthony Trewavas. Trewavas was also one of the experts quoted by the SMC in their media release that had such an impact on the reporting of the Seralini study.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">In his SMC comments, which ended up being quoted in well over 20 different publications worldwide, Trewavas accuses the researchers of using a cancer-prone rat and claims: &#8220;[A] line [of rats] which is very susceptible to tumours can easily bias any result.&#8221; This line of argument was also developed for the SMC by another expert, Maurice Moloney who says Sprague-Dawley rats frequently develop mammary tumours</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">It is this cancer-prone rat claim, which Trewavas and Moloney first set running, that more than any other underpins the Chassy-Miller allegation of fraud. The suggestion is that the study was deliberately designed to generate tumours, i.e. that Seralini and his team intentionally chose the Sprague-Dawley rat for their research in order to produce exactly the result they wanted &#8211; cancer!</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">But although variants on this claim have been widely reported, there are a number of problems with it. Not only is this line of rats the same one that Monsanto used for the study that underlies the regulatory approval of this GM maize (NK603), but Sprague-Dawley rats have also been used repeatedly in toxicology and carcinogenesis trials, including long-term ones. They were even used in industry’s own two-year research studies submitted to regulators to support the regulatory approval of glyphosate – the active ingredient in Monsanto&#8217;s Roundup, one of the two substances that Seralini&#8217;s team were researching.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">And the fact that this strain of rat has a 30%-plus tendency to “spontaneous” cancers across its lifetime actually means it a good model for humans, who have a similar susceptibility to the disease. What&#8217;s more, even allowing for the Sprague-Dawley rats having a tendency to spontaneous tumours, Seralini&#8217;s team found the rats fed on either the GM maize or the herbicide suffered an increase in the number of tumours and they had an earlier onset when compared to those in the control group. The researchers also took account of the spontaneous tumour issue by comparing their results to the rates of similar types of tumour in other published studies using the same strain of rat.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">This is not to say that the Seralini study does not have its shortcomings. It&#8217;s true that the study had fewer rats than are recommended for cancer studies, but Seralini did not set out to look for tumours. His study was a chronic toxicity one that unexpectedly found striking evidence of increased tumours in the treated rats. Given this finding, the onus should now be on Monsanto to fund a full-scale carcinogenicity study using larger groups of rats to prove that its products are safe – something it has so far failed to do.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Angelika Hilbeck of the Swiss Federal Institute of Technology (ETH Zurich) describes the &#8220;wrong rat&#8221; argument first put forward by Trewavas and Moloney as &#8220;absurd&#8221;. Hilbeck says, &#8220;Seralini chose the same strain of rat as Monsanto. Do we really think that a substance should be tested on an animal that is not sensitive to it? With these defamations they wanted to distract us from the fact that Seralini used the same methodology as Monsanto. Because if you take Seralini seriously as a researcher, you have to take seriously his study and the comparison with Monsanto&#8217;s study. That would put into question Monsanto&#8217;s study and hence the approval of GM maize.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Double standards used to condemn studies showing risk</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">In fact, many of the charges that have been made against the Seralini study could be levelled against the studies that have been used to approve GM crops, which are less detailed than Seralini&#8217;s and typically shorter-term. This is why a report by the European Network of Scientists for Social and Environmental Responsibility (ENSSER) concluded that a careful comparison of the Seralini rat feeding trial with Monsanto trials shows that if the Seralini experiments are considered insufficient to demonstrate harm, then those carried out by Monsanto cannot prove safety. This is because, whatever its limitations, Seralini&#8217;s study was conducted to generally higher scientific standards than the studies underlying GM food approvals.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">ENSSER highlights the double standards whereby studies on GM crops like Seralini&#8217;s that show adverse effects are subjected to obsessive yet often poorly justified criticism of their experimental and statistical methods, while those like Monsanto&#8217;s that claim safety are taken at face value. In this way risk is assessed in an asymmetrical fashion so that the burden of proof is not on the biotech industry to provide adequate evidence of the safety of its products, but is on public researchers like Seralini to prove harm beyond any doubt. Other experts have echoed the charge of double standards, including around 140 French scientists who, in a public statement published in Le Monde, declared that it was contrary to scientific ethics to damn an experimental protocol when it gave results that were not wanted, while accepting it when it gave results that were. </SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">These double standards can also be seen in the ipetition demanding that Seralini hand over all of his raw data to his critics. Those championing the petition have no history of demanding from Monsanto full public disclosure of all the raw data underlying its studies supporting safety (the industry studies on glyphosate, for example, are kept secret under &#8216;commercial confidentiality&#8217; agreements between industry and regulators). This is why Seralini has said he will undertake full disclosure when the same level of disclosure takes place for all the studies underlying GM food approvals, so that like can be compared with like.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Public science and private interests</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">One of the early UK signatories of the ipetition, as well as a co-signatory, like Prof. Trewavas, of the letter to Food and Chemical Toxicology from Prakash, Chassy and Miller, is Prof. Chris Leaver. Leaver, like Trewavas,&nbsp;&nbsp;&nbsp; is a GM scientist. He is also a former advisor to the Science Media Centre and a former consultant to the GM/agrochemical giant Syngenta. Since 1984 Prof. Leaver has also been on the Governing Council of the UK&#8217;s leading public plant biotech institute, the John Innes Centre – something else he has in common with Prof. Trewavas, who was also for several years on the JIC&#8217;s Governing Council.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The JIC has been a key player in the criticism of Seralini. This is apparent as soon as you look at the SMC&#8217;s three media releases on the study. The first quoted eight experts including a senior scientist at the JIC and a former member of its Governing Council (Trewavas). The second quoted just one expert, Cathie Martin of the JIC. The third quoted five experts, of which three, including Cathie Martin, were from the JIC.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">What makes this predominance particularly revealing is that the scientists in question are not experts on toxicology or animal studies. Their expertise is in plant genetics and GM. What&#8217;s more, the JIC and its Sainsbury Laboratory have had tens of millions of pounds in investment from GM giants like Syngenta. In fact, they are so dependent on the public acceptance of GM that a previous acting director of the JIC confided to his local paper that any major slowdown or halt in the development of GM crops &#8220;would be very, very serious for us&#8221;.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">These vested interests are personal as well as institutional. Cathie Martin, for instance, says in her JIC profile, &#8220;I am inventor on seven patents and I recently co-founded a spin-out company (Norfolk Plant Sciences) with Professor Jonathan Jones FRS, to bring the benefits of plant biotechnology to Europe and the US.&#8221; Jones, who is quoted along with Martin in one of the SMC releases, co-founded another biotech firm, Mendel Biotechnology, which has Monsanto as its &#8220;most important customer and collaborator&#8221;.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The failure of Jones, who is also an advisor to Mendel Biotechnology, to be more explicit about his industry links, has generated controversy. Yet journalists are given no indication of these kind of conflicts of interest by the SMC&#8217;s releases, as the journalist Joanna Blythman has noted: &#8220;The SMC introduced these experts to the media solely by listing the universities and public institutions that employ them, failing to give the full flavour of their interests.&#8221; And the problem goes much wider than the JIC, as Blythman notes with regard to the experts quoted in the SMC&#8217;s first media release: &#8220;seven out of eight are either evangelical advocates of GM food, or have received funding from, or worked with, prominent biotech corporations.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Take, for instance, the very first expert quoted by the SMC, Prof. Maurice Moloney. This year, the SMC has featured Moloney in no fewer than four different media releases on GM. They typically identify him only as &#8220;Institute Director and Chief Executive, Rothamsted Research&#8221;, which is an independent charitable agricultural research centre. What journalists aren&#8217;t told is that Moloney is so enamoured of GM that he drives around in a Porsche with a GMO number plate, and has a CV to match. He is the inventor on more than 300 patents and his GM research underpins one of Monsanto&#8217;s main GM crops. He has also founded his own GM company in which the GM giant Dow AgroScience was an investor. The fact that Prof. Moloney&#8217;s career and business interests have long been centered around GM is not something the SMC seems to think journalists need to know.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Letters to journal fail to disclose conflicts of interest</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">This pattern of significant but undisclosed conflicts of interest is relevant to not only the majority of the SMC&#8217;s experts but also to many of Seralini&#8217;s other critics, including those responsible for the twenty or so letters published by Food and Chemical Toxicology in response to Seralini&#8217;s paper. Some of the letter writers are, in fact, exactly the same people that the SMC quotes. They are also often to be found amongst the earliest signatories of the AgBioWorld ipetition. Maurice Moloney, for example, not only turns up twice in the SMC&#8217;s media rebuttals of Seralini, but comes in at no. 11 on the list of ipetition signatories, and he wrote a letter to the journal.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Another letter writer demanding retraction is Prof. Mark Tester. Like Moloney and the JIC, Tester is a firm favourite with the SMC, featuring in three of this year&#8217;s SMC&#8217;s media releases and in many more over the years. He was already a favoured expert a decade ago when the SMC was accused of orchestrating a spin campaign to discredit a BBC drama on GM crops. The University of Adelaide staff directory broadens out Prof. Tester&#8217;s academic profile in a way the SMC never has: &#8220;His commercial acumen is clear from his establishment of private companies and successful interactions with multinational companies such as Monsanto, Syngenta, Bayer and Pioneer-DuPont.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Many other letter writers also have undisclosed industry links. Take, for instance, Martina Newell-McGloughlin. She identifies herself as the director of the International Biotechnology Program at the University of California/Davis, but fails to mention that the Program is funded by the likes of Monsanto, Syngenta, DuPont and Bayer. Another letter writer and a colleague at UC Davis, Kent Bradford, has consulted for Monsanto. Lucia de Souza wrote to the journal with Leila Macedo Oda on behalf of ANBio – the Brazilian Biosafety Association, without mentioning that ANBio&#8217;s funders include Monsanto, Bayer, and DuPont.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Then there are the letter writers who fail to mention their previous employers, like Andrew Cockburn, Monsanto&#8217;s former director of scientific affairs (Europe and Africa); L. Val Giddings, former Vice President of the Biotechnology Industry Organisation; and Sivramiah (Shanthu) Shantharam, former Syngenta man and until recently head of the biotech industry&#8217;s main lobby group in India. </SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Even letter writers who at first glance seem like they must be entirely independent of the biotech industry can turn out to have links. Take, for instance, Erio Barale-Thomas, one of the few toxicologists to criticize the Seralini paper in the journal. Barale-Thomas, who says he writes on behalf of the Administrative Council of the French Society of Toxicological Pathology, takes Seralini to task for his failure to declare a conflict of interest in his paper, namely that Seralini is president of CRIIGEN, an independent research group with concerns about GM, which contributed funding to the research. Yet CRIIGEN&#8217;s contribution to funding the study was declared in the paper, while Barale-Thomas does not disclose in his letter his own biotech interests. He is not only principal scientist at Janssen Biotech, but immediately prior to that he worked for the GM crop and agrochemical giant Bayer CropScience.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Another French scientist among the letter writers is Prof. Marc Fellous, whose declared connections are academic posts in the sphere of human genetics. What he doesn&#8217;t mention is that he heads up the French Association of Plant Biotechnology, which lobbies for GM crops and has been so aggressive in its attacks on Seralini that last year he successfully sued Fellous for defamation.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Science or ideology?</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Another letter writer is the pathologist Sir Colin Berry. Like Trewavas, Berry is an advisor to the Scientific Alliance, an organization which campaigns on environmental issues, particularly climate change, energy policy and agriculture. It is pro-GM, pro-nuclear, and sceptical about climate change. Its director, Martin Livermore, runs an agri-food PR consultancy, prior to which he did PR for the GM giant DuPont. The Alliance was established by the lobby firm Foresight Communication with money from right-wing business interests.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Trewavas is one of only a couple of scientists who not only signed onto the Prakash, Chassy, Miller letter but also sent their own letter of complaint to the journal. Trewavas concludes it like this: &#8220;this paper and this journal have dealt the value of evidence-based knowledge a serious blow and it can only be rectified if the paper is withdrawn by the authors with an apology for misleading the public and the scientific community alike… Ideology and politics must be kept out of scientific study or we all suffer.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">It is revealing that critics like Berry and Trewavas claim to champion an evidence-based approach while operating out of lobby groups that attack the scientific consensus on issues like climate change. Berry, incidentally, is also a shareholder in the company that owns the aggressively libertarian online magazine Spiked, which also promotes climate scepticism. Fiona Fox, the director of the Science Media Centre, was a long-time affiliate of the anti-environmental LM network that are behind Spiked.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The network around AgBioWorld also contains people with similar attitudes on environmental issues. These include Henry Miller, who co-wrote the article accusing Seralini of fraud, and AgBioWorld&#8217;s co-founder Greg Conko of the Exxon-funded Competitive Enterprise Institute, which specializes in denialist &#8220;straight talk on global warming.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Given this, it is ironic that AgBioWorld&#8217;s Seralini petition was set up in the name of &#8220;the scientific community.&#8221; Similarly, Maurice Moloney says in his letter to Food and Chemical Toxicology that he thinks he can speak &#8220;for the vast majority of the biological sciences community.&#8221; But as we have seen, Moloney and many of the other letter writers link to a narrow and heavily commercialised sector of the biological sciences, albeit one with powerful backers. And some in this community have links to extremist lobby groups more concerned with ideology than evidence.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Peeling the GM onion</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Identifying the real forces behind the front-men and carefully selected experts of &#8220;the scientific community&#8221; can be like peeling back the layers of an onion. Take Anthony Trewavas, the scientist who first helped get the cancer-prone rat claim into circulation. In 2001 Prof. Trewavas was named in the High Court in London as the source of a letter published in a Scottish newspaper that made libelous claims against GM critics (Greenpeace wins damages over professor&#8217;s &#8220;unfounded&#8221; allegations). Trewavas subsequently denied being the author of the libel letter published under his name, though he did admit circulating the material, which he said he had got from AgBioWorld. He said it had been written by a &#8220;lady in London&#8221; but &#8220;she&#8221; later turned out to be a front for the same Monsanto PR people who covertly directed the campaign that resulted in Nature&#8217;s apparent retraction of Chapela&#8217;s GM maize paper.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Trewavas, a long-time associate of Prakash and AgBioWorld, also played a notable role in that campaign. In that case, Trewavas encouraged people to demand Chapela be fired by the University of California, Berkeley, unless he handed over his maize samples for checking: &#8220;We should be asking Berkeley to request Chapela to release his samples so that they at least can be checked&#8230; Refusal to do so should then be used to request Berkeley to relinquish Chapella&#8217;s [sic] position.&#8221; Such calls to arms against Chapela were mostly posted on the AgBioWorld listserv. This use of the listserv eventually enabled Monsanto&#8217;s covert orchestration of the campaign to be exposed.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The attack dog in the night-time</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Interestingly, as the attacks on Prof. Seralini and his paper spread across both mainstream and social media, AgBioWorld&#8217;s listserv went missing. In the two months following the publication of Seralini&#8217;s paper, not a single bulletin went out on the listserv that played such a pivotal role in achieving retraction of the Mexican maize paper.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">AgBioWorld&#8217;s sudden silence calls to mind a famous exchange in The Memoirs of Sherlock Holmes:</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Detective: &#8220;Is there any other point to which you would wish to draw my attention?&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Holmes: &#8220;To the curious incident of the dog in the night-time.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Detective: &#8220;The dog did nothing in the night-time.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Holmes: &#8220;That was the curious incident.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">With Seralini, it&#8217;s the curious silence of Monsanto&#8217;s attack dog that suggests that this time the covert PR war is being conducted by other means.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">If the silence of AgBioWorld&#8217;s listserv is suggestive, so too is the attempt to silence GMWatch. Within days of the publication of the Seralini paper, our website came under major DDOS (Distributed Denial of Service) attacks. The contours of the attacks followed the peaks of the controversy, with the two biggest and most debilitating attacks coinciding with days on which the major rebuttals of Seralini&#8217;s paper were published. The GMWatch website had by then become a clearing house for rapid responses in English to the attacks on Seralini. We have no proof as to who was behind the attacks – that&#8217;s hard to establish with DDOS. But oddly enough, an article in the Guardian about the retraction campaign against Quist and Chapela noted, &#8220;Just before the [Mexican maize] paper in Nature was publicly challenged, the server hosting the accounts used by its authors was disabled by a particularly effective attack which crippled their capacity to fight back.&#8221;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">More than a decade later history seems to be repeating itself in the covert war over GM crops.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Jonathan Matthews is the founder and director of GMWatch and has written numerous articles on the politics and spin around GM crops. He&#8217;s a contributing author to Thinker, Faker, Spinner, Spy: Corporate PR and the Assault on Democracy, eds Dinan and Miller (Pluto Press). Additional research: Claire Robinson, co-editor, GMWatch</SPAN></P></DIV></p>
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		<title>[GMO오픈세미나자료]GMO, 과연 안전한가? &#8211; 프랑스 세라리니 팀의 연구결과를 통해본 GMO의 유해성</title>
		<link>http://www.chsc.or.kr/?post_type=group&#038;p=5084</link>
		<comments>http://www.chsc.or.kr/?post_type=group&#038;p=5084#comments</comments>
		<pubDate>Mon, 12 Nov 2012 15:29:32 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[GMO반대]]></category>
		<category><![CDATA[Séralini]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[몬산토]]></category>
		<category><![CDATA[살충제]]></category>
		<category><![CDATA[인체유해성]]></category>
		<category><![CDATA[장기독성]]></category>

		<guid isPermaLink="false">http://www.chsc.or.kr/?post_type=group&#038;p=5084</guid>
		<description><![CDATA[GMO, 과연 안전한가? - 프랑스 세라리니 팀의 연구결과를 통해본 GMO의 유해성 최근 GMO관련 장기독성 연구를 진행한 프랑스 세라리니팀의 연구결과를 둘러싸고 세계적인 논쟁이 일어나고 있습니다. 이 주제에 대해 아래와 [...]]]></description>
				<content:encoded><![CDATA[<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255);"><font face="Gulim" size="4"><b>GMO, 과연 안전한가?</b></font></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255);"><font face="Gulim" size="3"><b>- 프랑스 세라리니 팀의 연구결과를 통해본 GMO의 유해성</b></font></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;"></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;">최근 GMO관련 장기독성 연구를 진행한 프랑스 세라리니팀의 연구결과를 둘러싸고 세계적인 논쟁이 일어나고 있습니다. 이 주제에 대해 아래와 같이 오픈세미나를 진행했습니다.&nbsp;</div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;">발제자료를 첨부하니 관심있으신 분들은 첨부파일을 다운로드 받으세요. 의 많은 참가 바랍니다. 발제자료는 박상표 선생님의 주발제문만 있습니다.</div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;">첨부된 자료 중 한가지는 한글문서로 발제문이고 나머지 한가지는 발제문을 PPT파일로 요약한 자료입니다.&nbsp;</div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;"></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;"><b>일시 : 11월 8일(목요일) 저녁 7시30분</b></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;"><b>장소: 건강과대안 사무실(종로3가역 7번출구 또는 안국역 4번출구)</b></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;"><b>패널 : 박상표(건강과대안 운영위원)</b></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;"><b>&nbsp; &nbsp; &nbsp; &nbsp; 최준호(환경운동연합 생명활동국장)</b></div>
<div style="color: rgb(85, 85, 85); font-family: Gulim; background-color: rgb(255, 255, 255); font-size: small;"><b>&nbsp; &nbsp; &nbsp; &nbsp; 김병수(시민과학센터 부소장)</b></div>
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		<title>[GMO] 세라리니 논문 폄하한 EFSA 이해관계 충돌</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3564</link>
		<comments>http://www.chsc.or.kr/?post_type=reference&#038;p=3564#comments</comments>
		<pubDate>Thu, 18 Oct 2012 17:28:40 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[EFSA]]></category>
		<category><![CDATA[glyphosate]]></category>
		<category><![CDATA[NK603]]></category>
		<category><![CDATA[글리포세이트]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[안전성]]></category>
		<category><![CDATA[유전자조작 옥수수]]></category>
		<category><![CDATA[이해관계 충돌]]></category>
		<category><![CDATA[장기독성]]></category>
		<category><![CDATA[종양]]></category>

		<guid isPermaLink="false">http://www.chsc.or.kr/?post_type=reference&#038;p=3564</guid>
		<description><![CDATA[1.EFSA criticised by auditors over conflicts of interest2.EFSA on health effects of interaction between GMOs and herbicideshttp://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14315:court-of-auditors-slams-efsaNOTE: The European Court of Auditors has slammed the European Food Safety [...]]]></description>
				<content:encoded><![CDATA[<p><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">1.EFSA criticised by auditors over conflicts of interest</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">2.EFSA on health effects of interaction between GMOs and herbicides<BR></SPAN><BR><A href="http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14315:court-of-auditors-slams-efsa">http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14315:court-of-auditors-slams-efsa</A><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><STRONG>NOTE: </STRONG>The European Court of Auditors has slammed the European Food Safety Authority (EFSA) for its inadequate management of conflicts of interest which it says is &#8220;not robust enough.&#8221;</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The Court &#8211; the independent audit institution of the European Union, whose job it is to examine whether the EU&#8217;s monies are being used in accordance with the rules &#8211; found serious shortcomings in the policies and procedures followed by EFSA.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The problems included EFSA not screening thoroughly the declared conflicts of interests of the scientists it appointed. EFSA, for instance, failed to do anything about a conflict of interest involving two experts reviewing food substances relevant to a company that they were simultaneously providing professional advice to. The Court&#8217;s report also criticises the presence of industry figures on EFSA&#8217;s management board. </SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The Court&#8217;s findings come as no surprise. Earlier this year the European Parliament postponed approval of EFSA&#8217;s budget in the light of all the problems over conflicts of interest at the agency.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">In fact, EFSA and its GMO Panel have been riven with such conflicts for years. And in May of this year the Chair of EFSA&#8217;s Management Board, which should be taking the lead in tackling the problem, was forced to quit because of her own flagrant industry links. </SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Disturbingly, all the concern over conflicts of interest at EFSA didn&#8217;t stop the European Commission earlier this year from nominating a food industry lobbyist and former Monsanto employee to become a member of EFSA&#8217;s Management Board.<BR></SPAN><SPAN style="FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal"><A href="http://www.testbiotech.org/en/node/631" target=_blank>http://www.testbiotech.org/en/node/631</A></SPAN></SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The resulting controversy made the Commission back down over that nomination, but there has long been similar controversy over EFSA&#8217;s GMO panel. At one point Friends of the Earth Europe <A href="http://www.bangmfood.org/quotes/24-quotes/29-regulatory-breakdown" target=_blank>reported</A> that a member of the GMO panel had direct financial links with the biotech industry while several others had indirect ones. FOEE even found that two members of the GMO panel had appeared in promotional videos for the biotech industry. </SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">FOEE also reported that several members of the GMO panel, including its then chair, had also been involved in a project tasked with agreeing procedures that would &#8220;facilitate market introduction of GMOs in Europe, and therefore bring the European industry in a competitive position.&#8221; As part of this, the chair of the GMO panel sat on a working group for the project alongside staff from Monsanto, Bayer and Syngenta. EFSA, of course, is supposed to be &#8220;the independent voice of science&#8221; guiding EU institutions.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">EFSA claims it has made changes that are putting its house in order. But the scepticism about this has only been increased by EFSA&#8217;s rapid rebuttal of the Seralini paper. </SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The concerns centre on the fact that EFSA seems to be applying standards to Seralini&#8217;s study that it fails to apply to the far less adequate studies underlying its own GM crop approvals, and also that EFSA appears to be trying to stifle debate and sweep the Seralini study under the carpet rather than seeking further investigation of the issue. In addition, both of the peer reviewers overseeing EFSA&#8217;s preliminary response to Seralini&#8217;s paper have also been accused of suffering conflicts of interest of one sort or another. </SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><A style="FONT-SIZE: 14px; COLOR: #336699; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif" href="http://www.gmwatch.org/component/content/article/14296" target=_blank>http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14296</A><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">As a result, Corinne Lepage MEP, the former French Environment Minister who heads up the board of Seralini&#8217;s institute, is now calling for the executive director of EFSA, Catherine Geslain-Laneelle, to resign.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><A style="FONT-SIZE: 14px; COLOR: #336699; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif" href="http://www.gmwatch.org/component/content/article/14286" target=_blank>http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14286</A><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">For Lepage, what adds to the sense that something is seriously awry at EFSA is the fact that the criticisms contained in EFSA&#8217;s response do not read like carefully considered opinions but like a rapidly assembled copy/paste job of points already circulated by others, and which largely fail to stand up to serious scrutiny.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">This is well exemplified by what happened at a recent EFSA press conference (item 2), where apparently EFSA&#8217;s Geslain-Laneelle &#8220;recalled the EFSA&#8217;s preliminary review of Seralini&#8217;s study, which was released last week, that the Sprague-Dawley strain of rats used in the experiments has been shown to be susceptible to developing tumours spontaneously, particularly as they grow older, making it difficult to interpret the results [of Seralini's study].&#8221; (item 2 below)</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">But although this claim has been widely made, the Sprague-Dawley (SD) rat is not only routinely used by industry in its studies to gain approval for GM foods, it is also used in *long-term* toxicity and carcinogenicity tests performed by Monsanto on glyphosate to gain marketing approval for it in the EU. And the European Network of Scientists for Social and Environmental Responsibility (ENSSER) reports that the National Toxicology Program of the U.S. Department of Health and Human Services uses the same strain of rat as Seralini in its 2-year studies, uncontested. They also found from a &#8220;brief, quick and still preliminary literature search of peer-reviewed journals&#8221; that SD rats were also used:</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">- in 36-month studies by Voss et al. (2005);</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">- in 24-month studies by Hack et al. (1995), Klimisch et al. (1997), Minardi et al. (2002),</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Soffritti et al. (2006) and Gamez et al. (2007);</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">- in 18-month studies by Lee et al. (2010); and</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">- in 12-month studies by Perry et al. (1981), Conti et al. (1988), Morcos &#038; Camilo </SPAN><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">(2001), Flamm et al. (2003) and Gutierrez et al. (2011).</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Four of these studies had been published in the journal Food and Chemical Toxicology &#8211; the same journal that published Seralini&#8217;s study.<BR></SPAN><SPAN style="FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal"><A href="http://www.gmwatch.org/latest-listing/51-2012/14288">http://www.gmwatch.org/latest-listing/51-2012/14288</A></SPAN></SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">As Mute Schimpf of Friends of the Earth Europe recently commented: &#8220;For the past decade, EFSA has consistently sided with the biotech industry and disregarded health or environment concerns about genetically modified crops. Instead of picking holes in independent, peer-reviewed research, it should be taking public concerns seriously and making long-term safety tests for genetically modified foods compulsory in the EU. The reaction from EFSA shows their double standards. If they had been as thorough with Monsanto&#8217;s applications as they were with this new research then no GMO would have been approved in the EU.&#8221;</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><A style="FONT-SIZE: 14px; COLOR: #336699; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif" href="http://www.gmwatch.org/component/content/article/14270" target=_self>http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14270</A><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">&#8212;</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">&#8212;</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><STRONG>1.EFSA criticised by auditors over conflicts of interest</STRONG></SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Corporate Europe Observatory, October 11 2012</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><A href="http://corporateeurope.org/pressreleases/2012/efsa-criticised-auditors-over-conflicts-interest" target=_blank><SPAN style="COLOR: #336699; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal">http://corporateeurope.org/pressreleases/2012/efsa-criticised-auditors-over-conf</SPAN></SPAN><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">licts-interest</SPAN></A><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Brussels &#8211; The European Court of Auditors (ECA) has sent a highly critical message to four of the EU agencies in a report published today, condemning their failure to manage conflicts of interest adequately.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The Court has carried out an investigation into conflict of interests policies at the European aviation safety agency (EASA), European chemicals agency (ECHA), European food safety agency (EFSA) and the European Medicines agency (EMA). The EASA came out worst in the score report, but significant shortcomings were identified at EMA and EFSA as well.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Nina Holland of Corporate Europe Observatory said:</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">&#8220;This report confirms that there is no effective system in place at the agencies to ban conflicts of interest or to stop staff going through the revolving doors between the agencies and industry. Ongoing conflicts of interest at EFSA and the EMA jeopardise food safety and public health. The agencies have so far failed to take the action which is so badly needed&#8221;.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The auditors’ report stands in stark contrast to the praise that recently came from Ernst &#038; Young, hired by EFSA to carry out an evaluation of the agency.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Holland added that EFSA for its part was twisting the Court&#8217;s message by emphasising the observation that EFSA&#8217;s system to deal with conflicts of interest seems &#8216;more developed&#8217; than that of some of the other agencies. She argued that even though EFSA has recently made some changes to its policy and practices, it was not enough to claim that all problems had been solved.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The report also criticises the presence of industry figures on EFSA’s management board. This threat to EFSA’s impartiality, it says, is worsened by the fact that three of these organisations are at the same time represented on the Stakeholder Consultative Platform. This is a clear message to the EU institutions that are about to start a revision of the EFSA founding regulation, where this could be changed.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The ECA report can be found at:</SPAN><A style="FONT-SIZE: 14px; COLOR: #336699; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif" href="http://eca.europa.eu/portal/pls/portal/docs/1/17190743.PDF" target=_blank>http://eca.europa.eu/portal/pls/portal/docs/1/17190743.PDF</A><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Contact:</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Nina Holland, Corporate Europe Observatory + 31 6 30285042</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">&#8212;</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">&#8212;</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><STRONG>2.EFSA on health effects of interaction between GMOs and herbicides</STRONG></SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Joanna Sopinska</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Europolitics, 12 October 2012</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><A href="http://www.europolitics.info/sectorial-policies/efsa-on-health-effects-of-interaction-between-gmos-and-herbicides-art344015-11.html" target=_blank><SPAN style="COLOR: #336699; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal">http://www.europolitics.info/sectorial-policies/efsa-on-health-effects-of-intera</SPAN></SPAN><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">ction-between-gmos-and-herbicides-art344015-11.html</SPAN></A><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Catherine Geslain-Laneelle, executive director of the European Food Safety Authority (EFSA), has admitted that there are two separate legislative tracks in the EU to examine the adverse health effects of diets containing genetically modified organisms (GMOs) and herbicides. At a press briefing, held on 12 October in Brussels, she explained that EU law does not require tests to be conducted on the health effects of the interaction between GMOs and herbicides.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">The comment came after the publication, at the end of September, of a study by Gilles-Eric Seralini, which found that rats fed over two years with authorised GM maize NK603 and dosed with the herbicide called Roundup at permitted levels suffered from tumours and died earlier than rats fed a non-GM diet. An earlier test of NK603 maize in rats in a 90-day feeding trial (the current regulatory norm), sponsored by its producer &#8211; Monsanto company &#8211; showed no adverse effects. Geslain-Laneelle rejected claims that the 90-day feeding trial is not sufficient to estimate the risk and grant the authorisation for use or cultivation of GMOs in the EU.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Several food safety NGOs criticise EU legislation for not requiring long-term feeding trials in the area of GMOs. Referring to Seralini’s study, Geslain-Laneelle pointed to the fact that there were many other studies made on the adverse health effects on cows and sheep of diets containing GM crops, which also lasted two years. She recalled the EFSA&#8217;s preliminary review of Seralini&#8217;s study, which was released last week, that the Sprague-Dawley strain of rats used in the experiments has been shown to be susceptible to developing tumours spontaneously, particularly as they grow older, making it difficult to interpret the results.</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">NEXT STEPS</SPAN><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><BR style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif"><SPAN style="FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-FAMILY: Verdana, Geneva, Arial, Helvetica, sans-serif">Geslain-Laneelle confirmed that the EFSA will publish its final review of Seralini’s study by the end of October. To this end, the EU food health watchdog asked Seralini to provide, by 12 October, additional information on his study. The scientist said, however, that he will not release his data until the raw data underpinning the authorisation of NK603 in Europe are also made public. Geslain-Lanéelle referred to this request, underlining that such data are made available on request. At the time when Europolitics went to press, on 12 October, no reply was received by the EFSA from Seralini. &#8220;Regardless if we receive additional information from Seralini or not, we would publish our final review,” an EFSA spokesman told Europolitics. He explained that the paper will also be based on national reviews. Germany, Belgium, the Netherlands and France are expected to contribute with their own assessments, the spokesman confirmed.</SPAN></p>
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		<title>[GMO] Excess Cancers and Deaths with GM Feed: the Stats Stand Up</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3563</link>
		<comments>http://www.chsc.or.kr/?post_type=reference&#038;p=3563#comments</comments>
		<pubDate>Thu, 18 Oct 2012 17:22:43 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[glyphosate]]></category>
		<category><![CDATA[NK603]]></category>
		<category><![CDATA[글리포세이트]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[안전성]]></category>
		<category><![CDATA[유전자조작 옥수수]]></category>
		<category><![CDATA[장기독성]]></category>
		<category><![CDATA[종양]]></category>

		<guid isPermaLink="false">http://www.chsc.or.kr/?post_type=reference&#038;p=3563</guid>
		<description><![CDATA[NOTE: Over and over again the claim has been made that Seralini&#8217;s recently published study, which found high levels of tumours in rats given GM feed and tiny [...]]]></description>
				<content:encoded><![CDATA[<p><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><STRONG>NOTE:</STRONG> Over and over again the claim has been made that Seralini&#8217;s recently published study, which found high levels of tumours in rats given GM feed and tiny amounts of Roundup, can be safely ignored because he didn&#8217;t use sufficient numbers of experimental animals. But in the following article Prof. Peter Saunders, like the renowned French statistician Paul Deheuvels, points out that the smaller numbers actually make Seralini&#8217;s findings MORE &#8211; not less &#8211; significant. </SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Prof. Peter Saunders is Emeritus Professor of Mathematics at King&#8217;s College London and a leading expert in Mathematical Biology. His recent work has focused on modelling physiological control and finding the cause of Type II diabetes. He is a Vice-President of the UK Parliamentary and Scientific Committee.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">&#8212;</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><br />
<H3>ISIS Report 16/10/12 <BR><A href="http://www.i-sis.org.uk/Excess_cancers_and_deaths_from_GM_feed_stats_stand_up.php">http://www.i-sis.org.uk/Excess_cancers_and_deaths_from_GM_feed_stats_stand_up.php</A><BR></H3><br />
<H1 align=center><BR>Excess Cancers and Deaths with GM Feed: the Stats Stand Up</H1><br />
<P><I>That cancers are found even with a small number of rats tested is strong evidence that the GM feed and herbicide are carcinogenic <A href="http://www.i-sis.org.uk/contact.php">Prof Peter Saunders</A> <BR></I></P><br />
<P align=center><B>Please circulate widely and repost, but you must give the URL of the original and preserve all the links back to articles on our website. If you find this report useful, please support ISIS by subscribing to our magazine <A href="http://www.i-sis.org.uk/subscribe">Science in Society</A>, and encourage your friends to do so. Or have a look at the <A href="http://www.i-sis.org.uk/onlinestore/books.php">ISIS bookstore</A> for other publications</B></P><br />
<P>In September 2012, the research team led by Gilles-Eric Séralini at the University of Caen published the findings of their feeding trial on rats to test for toxicity of Monsanto’s genetically modified (GM) maize NK603 and/or Roundup herbicide in the online edition of <I>Food and Chemical Toxicology </I>[1]. </P><br />
<P>Séralini and his colleagues had previously found evidence for toxicity of GM feed in data from Monsanto’s own experiments, which they had obtained through a Freedom of Information demand [2]. Monsanto challenged their conclusions and, to no one’s great surprise the European Food Standards Agency (EFSA) supported Monsanto [3]. So the team decided to run their own experiment, using an unusually large number of animals and over a period of about two years, roughly the life expectancy of the rats, rather than the usual 90 days required in toxicity trials including Monsanto’s.</P><br />
<P>What Séralini and his colleagues found was that NK603 and Roundup are not only both toxic as expected, but also carcinogenic, which was unexpected. The proportion of treated rats that died during the experiments was much greater than the controls; moreover, in almost all groups a higher proportion developed tumours, and the tumours appeared earlier.</P><br />
<P>As soon as the paper appeared, the GM lobby swung into action. In particular, the Science Media Centre (SMC), a London-based organisation partly funded by industry, quickly obtained quotes from a number of pro-GM scientists and distributed them to the media [4]. According to a report in <I>Times Higher Education</I> [5], the SMC succeeded in influencing the coverage of the story in the UK press and largely kept it off the television news.</P><br />
<P>Séralini has rebutted the pro-GM critics point by point on the CRIIGEN website [6]. &nbsp;The statistician Paul Deheuvels, a professor at the Université Pierre et Marie Curie in Paris and a member of the French Académie des sciences, has now drawn attention to another serious error in the criticisms [7]: the complaint that Séralini used only 10 rats per group when the OECD guidelines [8] recommend 50 for investigations on carcinogenesis. Because the experiments did not follow the accepted protocol, their results, they argue, can be safely ignored.</P><br />
<P>In the first place, this was not a wilful disregard of the guidelines. The experiment was designed to test for toxicity, and for that the recommended group size is 10.</P><br />
<P>But Deheuvels pointed out that the fact Séralini and his colleagues had used <I>smaller</I> groups than recommended makes the results if anything <I>more</I> convincing, not less. That is because using a smaller number of rats actually made it <I>less </I>likely to observe any effect. The fact that an effect was observed despite the small number of animals made the result all the more serious.</P><br />
<P>To see why, we have to look carefully at how common statistical tests are carried out. We begin with a null hypothesis, which as the name suggests is essentially the hypothesis that nothing unusual has happened. Here it is the hypothesis that rats fed on GMOs and/or herbicide are no more likely to develop cancer than the controls. Clearly, we would like to reject the null hypothesis if it is false and accept it if it is true. But statistics is about taking decisions in the face of uncertainty – if there were no uncertainty there would be no need to use statistics – and so however careful we are, we may come to the wrong conclusion.</P><br />
<P>There are two ways in which we can go wrong. On the one hand, we can make a “Type 1 error” in rejecting the null hypothesis when it is correct. Here that would mean reporting that GMO and/or herbicide are carcinogenic when they are not. Or, we can make a “Type 2 error” in accepting the null hypothesis when it is false. Here that would mean reporting that GMO and/or herbicide are not carcinogenic when in fact they are.</P><br />
<P>Naturally we would like to design experiments to make either of those probabilities as small as possible, but there is a problem. The two types of error are linked. We can reduce the probability of making a Type 1 error by requiring stronger evidence before we reject the null hypothesis. But if we do that we necessarily require less evidence to accept it, but that increases the probability of making a Type 2 error. We have to find a balance, and usually what we do is insist that the probability of a Type 1 error must be very small, conventionally 0.05. That’s the origin of the “significant at 5 percent” level. </P><br />
<P>A probability of 0.05 is very small, so what we are saying is that we will only accept that the effect is real if we can be convinced “beyond reasonable doubt”; and most of the time that makes sense. If you’re thinking of installing a new manufacturing process or a new way of running your farm, you want to be very confident that it really is better before you make a major investment. </P><br />
<P>It is not so obviously sensible when safety is concerned. If there is scientific evidence that a product is hazardous, then it is hardly surprising if the manufacturer would not want to withdraw it unless the evidence is very strong indeed. The rest of us, however, might take a different view. Are we really willing to accept NK603 maize, or Roundup herbicide, unless and until they have been shown beyond reasonable doubt to be carcinogenic? </P><br />
<P>The standard statistical test does seem to be the wrong way around, but that’s partly because so far we have only been considering the Type 1 error, the false positive. But as Deheuvels reminds us, there is also the Type 2 error, the false negative. If NK603 and/or the herbicide are actually carcinogenic, what is the probability that we will fail to observe that? </P><br />
<P>The way to reduce the probability of a Type 2 error is to use larger groups. <I>Because we would expect carcinogenicity to be slower to appear and harder to detect than toxicity</I>, <I>the group size for experiments on carcinogenicity should be larger than for toxicity, </I>and this is precisely what the OECD Guidelines require. </P><br />
<P>If the experiment had <I>not</I> detected carcinogenicity, that might have been because the groups were too small. As the experiment did detect it, that the groups were small is not an issue. &nbsp;The scientists who were asked to supply sound bites for the Science Media Centre were quick to object that Séralini and his group had used the protocol for testing toxicity rather than the one for carcinogenesis. Had they taken a moment to ask themselves why the two protocols are different, they would have realised that in using the toxicity protocol (and remember, that was because it was what the experiment was designed to test) Séralini and his group made it <I>less</I> likely that they would detect carcinogenesis. To criticise a result because the experiment was conducted in a way that was <I>more</I> conservative than required is totally unjustifiable.</P><br />
<H3>References</H3><br />
<OL type=1><br />
<LI>Séralini G-E, Mesnage R, Gress S, Defarge N, Malatesta M, Hennequin D and&nbsp; de Vendômois JS (2012),&nbsp; Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. <I>Food and Chemical Toxicity</I>. <A href="http://dx.doi.org/10.1016/j.fct.2012.08.005">http://dx.doi.org/10.1016/j.fct.2012.08.005</A><br />
<LI>Séralini G-E, Cellier D and de Vendômois JS (2007).&nbsp; New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity. <I>Archives of Environmental Contamination and Toxicity</I> 52, 596-602.<br />
<LI>EFSA review of statistical analyses conducted for the assessment of the MON863 90-day rate feeding study, 2007, <A href="http://www.efsa.europa.eu/en/efsajournal/doc/19r.pdf">http://www.efsa.europa.eu/en/efsajournal/doc/19r.pdf</A><br />
<LI>Science Media Centre press release: Expert Reaction to GM maize causing tumours in rats. 19 September 2012,<BR><A href="http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm">http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm</A>&nbsp;<br />
<LI>&nbsp;“Shock troops check ‘poor’ GM study”, Paul Jump, <I>Times Higher Education</I>, 4 October 2012.<br />
<LI>Criigen Research Team FAQs, accessed 12 October 2012, <A href="http://www.criigen.org/SiteEn/index.php?option=com_content&#038;task=view&#038;id=368&#038;Itemid=1" target=_blank>http://www.criigen.org/SiteEn/index.php?option=com_content&#038;task=view&#038;id=368&#038;Itemid=1</A><br />
<LI>De Heuvels P. <B>Étude de Séralini sur les OGM : pourquoi sa méthodologie est statistiquement bonne. <I>Le nouvel observateur Le Plus, 2012</I>, accessed 12 October 2012, <A href="http://leplus.nouvelobs.com/contribution/646458-etude-de-seralini-sur-les-ogm-pourquoi-sa-methodologie-est-statistiquement-bonne.html?utm_source=outbrain&#038;utm_medium=widget&#038;utm_campaign=obclick&#038;obref=obinsource">http://leplus.nouvelobs.com/contribution/646458-etude-de-seralini-sur-les-ogm-pourquoi-sa-methodologie-est-statistiquement-bonne.html?utm_source=outbrain&#038;utm_medium=widget&#038;utm_campaign=obclick&#038;obref=obinsource</A> </B><br />
<LI>OECD Guidelines for the Testing of Chemicals 451: Carcinogenicity Studies, 2009.&nbsp; <BR><A href="http://www.oecd-ilibrary.org/docserver/download/fulltext/9745101e.pdf?expires=1350053297&#038;id=id&#038;accname=freeContent&#038;checksum=BB6C78E3268AD83DB887899FF18E8147">http://www.oecd-ilibrary.org/docserver/download/fulltext/9745101e.pdf?expires=1350053297&#038;id=id&#038;accname=freeContent&#038;checksum=BB6C78E3268AD83DB887899FF18E8147</A> </LI></OL></SPAN></p>
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		<title>[GMO] 유전자조작 옥수수 쥐(The GM maize rats)</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3562</link>
		<comments>http://www.chsc.or.kr/?post_type=reference&#038;p=3562#comments</comments>
		<pubDate>Thu, 18 Oct 2012 17:03:21 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[glyphosate]]></category>
		<category><![CDATA[NK603]]></category>
		<category><![CDATA[글리포세이트]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[안전성]]></category>
		<category><![CDATA[유전자조작 옥수수]]></category>
		<category><![CDATA[장기독성]]></category>
		<category><![CDATA[종양]]></category>

		<guid isPermaLink="false">http://www.chsc.or.kr/?post_type=reference&#038;p=3562</guid>
		<description><![CDATA[The GM maize rats &#160; Author(s): Latha Jishnu Date: Oct 31, 2012]]></description>
				<content:encoded><![CDATA[<p><BR><br />
<H1 class=title>The GM maize rats </H1><br />
<DIV class=commentCount>&nbsp;</DIV><br />
<DIV class=authors style="MARGIN-TOP: 5px"><SPAN class=tagLabel>Author(s): </SPAN><A href="http://www.downtoearth.org.in/author/108">Latha Jishnu</A></DIV><br />
<DIV class=issueDate><SPAN class=tagLabel>Date: </SPAN>Oct 31, 2012<BR></DIV><!--</p>
<div class="taxonomy-terms"><span class="tagLabel">Tags:</span> <a href="/category/section/special-report" title="">Special Report</a>, <a href="/category/thesaurus/agriculture-6" title="">Agriculture</a>, <a href="/category/thesaurus/industry/biotechnology-industry" title="">Biotechnology Industry</a>, <a href="/category/thesaurus/criigen" title="">CRIIGEN</a>, <a href="/taxonomy/term/20703" title="">Crops</a>, <a href="/taxonomy/term/20436" title="">Down to earth</a>, <a href="/category/thesaurus/ensser" title="">ENSSER</a>, <a href="/taxonomy/term/13600" title="">European Union (EU)</a>, <a href="/category/thesaurus/gilles-eric-seralini" title="">Gilles-Eric Seralini</a>, <a href="/category/thesaurus/glyphosate" title="">glyphosate</a>, <a href="/taxonomy/term/8604" title="">GMOs</a>, <a href="/taxonomy/term/7313" title="">Health Effects</a>, <a href="/taxonomy/term/7502" title="">Herbicide</a>, <a href="/category/thesaurus/jack-heinemann" title="">Jack Heinemann</a>, <a href="/taxonomy/term/20777" title="">Latha Jishnu</a>, <a href="/taxonomy/term/7899" title="">Maize</a>, <a href="/category/thesaurus/maize-nk603" title="">maize NK603</a>, <a href="/taxonomy/term/20406" title="">Monsanto</a>, <a href="/category/thesaurus/sprague-dawley-rats" title="">Sprague Dawley rats</a>, <a href="/taxonomy/term/7578" title="">Toxicity Studies</a>, <a href="/category/thesaurus/university-caen" title="">University of Caen</a></div>
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<P>출처 : <A href="http://www.downtoearth.org.in/content/gm-maize-rats">http://www.downtoearth.org.in/content/gm-maize-rats</A><BR><BR>Findings of the Seralini lab on effect of Monsanto’s GM maize on rats set off a global furore</P></DIV><SPAN class=print-link></SPAN><br />
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<P>Three weeks ago, a university institute in Normandy, France, sparked fury, outrage and an astonishingly vicious battle between scientists across the world by publishing results of a two-year animal feeding study. The study involved one of the best known varieties of genetically modified (GM) maize and the most widely used glyphosate-based herbicide. The study was published by a team of scientists led by the highly regarded Gilles-Eric Seralini who heads the Institute of Biology at the University of Caen in France. </P><br />
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<TD style="BORDER-BOTTOM: rgb(204,204,204) 4px solid" vAlign=top align=left width=160 rowSpan=2><IMG height=176 alt="GILLES-ERIC SERALINI" src="http://www.downtoearth.org.in/dte/userfiles/images/24-1.jpg" width=150 align=left border=0></TD><br />
<TD>We are surprised by the violent and rapid reactions by scientists within 24 hours. Was it because of their financial interests?</TD></TR><br />
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<TD style="FONT-SIZE: 12px; PADDING-TOP: 8px; BORDER-BOTTOM: rgb(204,204,204) 4px solid" align=right><EM>— GILLES-ERIC SERALINI, HEAD OF INSTITUTE OF BIOLOGY, UNIVERSITY OF CAEN, FRANCE</EM></TD></TR></TBODY></TABLE><br />
<P>Seralini and his team of seven conducted a lifetime feeding trial of the herbicide-tolerant maize known as NK603, a product of agribiotech giant Monsanto of the US, and of its extensively used herbicide Roundup, on 200 rats for two years. Roundup kills weeds without harming the crops. It was the first time that the health impact of a GM crop and a widely used pesticide was studied for this length of time and in a more comprehensive manner than studies done by regulatory agencies, industries or by research institutes. The two-year study was designed to correspond with the expected lifetime of a normal rat whereas the industry practice is 90-day study. </P><br />
<P>The team used 100 female and 100 male rats. In both sets, some rats were fed NK603, some the GM maize sprayed with Roundup, and the third group was given drinking water with the lowest permissible limit of Roundup. A fourth, control group was fed a standard diet of the closest variety of non-GM maize. </P><br />
<P>The results were alarming, according to the peer-reviewed paper published in Food and Chemical Toxicology, a journal from the reputed Elsevier stable. Rats that fed on NK603 or given water containing Roundup died much earlier than the rats in the control group and developed hormonal and sex-related effects. Females developed significant mammary tumours, pituitary and kidney problems, while males died mostly from severe kidney failure. Up to 50 per cent of the male rats and 70 per cent of females died prematurely, compared with only 30 per cent and 20 per cent in the control group.</P><br />
<P><SPAN class=standalone-image style="WIDTH: 457px"><IMG title="In female rats, the largest tumours were five times more frequent than in males, with 93 per cent being mammary tumours. These were deleterious to health due to their large size and caused impediments to breathing or nutrition and digestion" height=248 alt="In female rats, the largest tumours were five times more frequent than in males, with 93 per cent being mammary tumours. These were deleterious to health due to their large size and caused impediments to breathing or nutrition and digestion" src="http://www.downtoearth.org.in/dte/userfiles/images/25-1.jpg" width=457 border=0><SPAN class=caption>In female rats, the largest tumours were five times more frequent than in males, with 93 per cent being mammary tumours. These were deleterious to health due to their large size and caused impediments to breathing or nutrition and digestion</SPAN></SPAN></P><br />
<P>The implications are extremely serious, says a press note issued by CRIIGEN, an independent organisation of scientific experts that studies genetically modified organisms (GMO), pesticides and impacts of pollutants on health and environment, on the research results. “They demonstrate the toxicity, both of a GMO with the most widely spread transgenic character and of the most widely used herbicide, even when ingested at extremely low levels (corresponding to those found in surface or tap water).” The scientists point out that these results call into question the adequacy of the current regulatory process which is used the world over in assessing the health risks associated with such products. They, therefore, demand that the market approval for these products should be immediately reviewed and urged the extension of the usual 90-day test to two years for agricultural GMOs. </P><br />
<P>“It was surprising. We didn’t expect the kind of tumours that we saw appearing in the rats in the fourth month (industry trials end at three months) of our experiment,” says Robin Mesnage, member of the Seralini research team who was in India to attend the conference of parties to the Convention on Biodiversity in Hyderabad. “And these tumours in rats eating the Roundup-tolerant GM maize began to appear so much earlier than in the control group.”</P><br />
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<TD style="BORDER-TOP: #000000 3px solid" bgColor=#eaeaea height=25><STRONG>Interview</STRONG></TD></TR><br />
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<TD style="PADDING-LEFT: 10px; PADDING-BOTTOM: 10px" align=middle><A href="http://www.downtoearth.org.in/content/major-health-implications-humans" target=_blank><IMG height=90 alt="MICHAEL ANTONIOU" src="http://www.downtoearth.org.in/dte/userfiles/images/26-1(1).jpg" width=150 align=left border=0></A></TD></TR><br />
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<TD style="PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; BORDER-BOTTOM: rgb(238,238,238) 1px solid"><A style="FONT-WEIGHT: bold; COLOR: rgb(0,84,166); TEXT-DECORATION: none" href="http://www.downtoearth.org.in/content/major-health-implications-humans" target=_blank>Major health implications for humans </A></TD></TR><br />
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<TD style="PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; COLOR: #2f2f2f; PADDING-TOP: 5px; BORDER-BOTTOM: rgb(238,238,238) 1px solid">Michael Antoniou, head of the Nuclear Biology Group in the UK, has been studying the health effects of genetically modified (GM) crops since 1995.</TD></TR></TBODY></TABLE></TD><br />
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<P>Explaining the genesis of the experiment, Mesnage said that the €3.2-million-study was conceived in 2008 when the first of the Seralini team’s researches into the effects of GM maize varieties on mammalian health was nearing completion. Those results which <FONT color=#ee2222>analysed Monsanto’s own 13-week “safety assurance study” by Bruce Hammond et al—the results were published in the very same Food and Chemical Toxicology in 2004—</FONT>had highlighted concerns over new side effects that were sex-related and dose-dependent. “Effects were mostly associated with the kidney and liver,” notes the paper by Seralini and others.</P><br />
<P>To see if the signs of liver and kidney toxicity escalated into something serious, Seralini’s team chose a chronic toxicity protocol as per OECD (Organisation for Economic Cooperation and Development) guidelines, which is the general rule. And as the current paper, “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize”, shows this, indeed, is the case. </P><br />
<P>But<FONT color=#ee2222> the biotech industry and its cheerleaders have reacted with fury and criticisms that have as quickly been rebutted by independent scientists.</FONT> Rejecting the findings, Monsanto says, “The study does not meet minimum acceptable standards for this type of scientific research, the findings are not supported by the data presented, and the conclusions are not relevant for the purpose of safety assessment.” (See ‘The company’s rebuttal’). It also makes the standard claim that “<FONT color=#ee2222>plant biotechnology has been in use for over 15 years without documented evidence of adverse effects on human or animal health or the environment</FONT>.” </P><br />
<P>Seralini’s professional standing—he has written over 100 scientific articles and has been a member of two French government commissions that oversee risk assessment of GMOs and monitor commercialised GMOs—has not stopped detractors from mounting personal attacks. But support has come from ENSSER (European Network of Scientists for Social and Environmental Responsibility) which says, “The vitriolic attacks evoked by the study reveal the lack of appropriate methodologies for long-term studies to assess the effects of life-time consumption of GM foods.”</P><br />
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<TD><SPAN style="FONT-WEIGHT: bold; FONT-SIZE: 15px">Company’s rebuttal </SPAN><br />
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<P><EM>Monsanto, developer of GM NK603 maize and Roundup herbicide, says:</EM></P><br />
<P><IMG height=134 alt=image src="http://www.downtoearth.org.in/dte/userfiles/images/24(5).jpg" width=200 border=0></P><br />
<UL><br />
<LI style="FONT-SIZE: 14px; MARGIN-BOTTOM: 12px; LINE-HEIGHT: 22px">Research protocol does not meet OECD standards<br />
<LI style="FONT-SIZE: 14px; MARGIN-BOTTOM: 12px; LINE-HEIGHT: 22px">Source and quality of maize used is unclear<br />
<LI style="FONT-SIZE: 14px; MARGIN-BOTTOM: 12px; LINE-HEIGHT: 22px">Absence of critical details on diet preparation, dietary intake<br />
<LI style="FONT-SIZE: 14px; MARGIN-BOTTOM: 12px; LINE-HEIGHT: 22px">Lack of data on changes in liver or kidney tissues<br />
<LI style="FONT-SIZE: 14px; MARGIN-BOTTOM: 12px; LINE-HEIGHT: 22px">Mortality rates, tumour incidence fall within historical norms<br />
<LI style="FONT-SIZE: 14px; MARGIN-BOTTOM: 12px; LINE-HEIGHT: 22px">Data presented highly selective<br />
<LI style="FONT-SIZE: 14px; MARGIN-BOTTOM: 12px; LINE-HEIGHT: 22px">Lack of statistical analysis for morta lity/tumour incidence endpoints </LI></UL></TD></TR></TBODY></TABLE></TD><br />
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<P>The quickest rejection of the study came from <FONT color=#ee2222>Maurice Moloney</FONT>, institute director and chief executive of Rothamsted Research, who said: “Although this paper has been published in a peer–reviewed journal, there are anomalies throughout the paper that normally should have been corrected or resolved through the peer-review process. For a paper with such potentially important findings, it would have been more satisfying to have seen something with a more conventional statistical analysis.” <FONT color=#ee2222>Moloney, who is said to hold more than 300 patents, was earlier with Calgene where he developed the world’s first transgenic oilseeds, which led to the development of RoundUp Ready Canola and other such crops. Calgene was acquired by Monsanto in 1997. </FONT></P><br />
<P>In response to the criticism, Seralini told Down To Earth that: “<FONT color=#ee2222>We are surprised by the violent and rapid reactions by scientists within 24 hours. Was it because of their financial interests? Or, were they involved in the insufficient assessment of agricultural GMOs on health?”</FONT> But not surprisingly, he adds, “The first reactions have come essentially from people who have not published any peer-reviewed scientific papers on mammalian or human physiological and toxicological studies. This is the case with Maurice Moloney who works on GMO development and patents, not on food safety.”</P><br />
<P>Moloney was the spearhead for a torrent of criticism from the industry and this has caused unease among independent scientists. Says Jack Heinemann, professor of molecular biology and genetics, University of Canterbury, New Zealand: “The reactions appeared shockingly quick and this is a cause for concern because I find it takes time to thoroughly read a scientific paper of this complexity.”</P><br />
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<TD style="BORDER-BOTTOM: rgb(204,204,204) 4px solid" vAlign=top align=left width=210 rowSpan=2><IMG height=168 alt="JACK HEINEMANN" src="http://www.downtoearth.org.in/dte/userfiles/images/25(23).jpg" width=200 align=left border=0></TD><br />
<TD>The reaction appears shockingly quick. It takes time to thoroughly read a scientific paper of this complexity</TD></TR><br />
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<TD style="FONT-SIZE: 12px; PADDING-TOP: 8px; BORDER-BOTTOM: rgb(204,204,204) 4px solid" align=right><EM>— JACK HEINEMANN, PROFESSOR OF MOLECULAR BIOLOGY AND GENETICS, UNIVERSITY OF CANTERBURY, NEW ZEALAND</EM></TD></TR></TBODY></TABLE><br />
<P>While most of the criticism was of a general nature, others were specific, referring to <FONT color=#ee2222>the type of rat used, the kind of statistical analysis, and the interpretation of the response to increasing concentrations of the agrichemicals, Roundup, or GM plant ingredient.</FONT> But here, too, a review of the seven studies of this kind since 2004 shows that all of these used approximately the same number of rats and all were conducted on the same kind of rat (Sprague Dawley) as the study by Seralini’s team. “The 2004 study by Hammond (Monsanto’s) used marginally more rats in the relevant control group, but was in my opinion less powerful statistically because of the inclusion of ‘reference’ control lines that were not fed on the near-isogenic non-GM diet,” says Heinemann who heads the independent Centre for Integrated Research in Biosafety.</P><br />
<P>But the voices of reason have been few in this current controversy which has redrawn ever more sharply the battle lines in the GM controversy. In the US, <FONT color=#ee2222>the Council for Biotechnology Information</FONT>, which speaks for the industry, describes the paper as “a bizarre study by French researchers”. It has put out a statement, among others, by Bruce M Chassy, professor emeritus of food science at the University of Illinois, as saying: “It is a well-planned and cleverly orchestrated media event. The study was designed to produce exactly what was observed and it was deliberately allowed to continue until grotesque and fear-evoking tumors developed.”</P><br />
<P>A clearly annoyed Seralini points out that to get official approval for commercialisation of NK603, Monsanto studied just 10 rats per group and used the same kind of rats. “If 10 rats is too small a number per group to reach a conclusion on safety like some of my critics are saying then NK603 and most agricultural GMOs should be forbidden.”</P><br />
<P>But while scientists are involved in increasingly acrimonious exchanges, governments have acted. Russia, for one, has temporarily suspended the import and sales of NK603 maize until the country is reassured about its safety, the consumer safety watchdog Rospotrebnadzor announced within days of the paper’s publication. It asked scientists at Russia’s Institute of Nutrition to review the study by Seralini et al and sought the comments of the European Commission on it.</P><br />
<P>France, for its part, ordered its food-safety agency Anses to quickly review the study and the Prime Minister pushed up the ante by declaring that his government would seek an immediate ban on the EU imports of the Monsanto product if the study’s findings were found conclusive. He put the scientific validation on fast track, demanding “a fast procedure, about a few weeks, to verify the scientific value of the study”. </P><br />
<P>India is interestingly poised in this controversy. Two years ago, the regulator of the Genetic Engineering Appraisal Committee gave permission to Monsanto India to conduct bio-safety research trials (second year field trial) on two GM maize hybrids: Hishell and 900M Gold containing stacked events MON 89034 &#038; NK603 at several state agricultural universities. Those trials are over and the company is reportedly awaiting approval for commercial release. Is the regulator taking note of the global uproar over the latest toxicological study?<BR><BR>===========================<BR><BR></P><br />
<H1 class=title>GM maize and its health implications for humans </H1><br />
<DIV class=commentCount><SPAN class=tagLabel>Author(s): </SPAN><A href="http://www.downtoearth.org.in/author/108">Latha Jishnu</A></DIV><br />
<DIV class=issueDate><SPAN class=tagLabel>Date: </SPAN>Oct 31, 2012<BR><A href="http://www.downtoearth.org.in/content/gm-maize-and-its-health-implications-humans">http://www.downtoearth.org.in/content/gm-maize-and-its-health-implications-humans</A><BR></DIV><!--</p>
<div class="taxonomy-terms"><span class="tagLabel">Tags:</span> <a href="/category/section/interview" title="">Interview</a>, <a href="/taxonomy/term/20436" title="">Down to earth</a>, <a href="/taxonomy/term/13586" title="">Europe</a>, <a href="/taxonomy/term/13602" title="">France</a>, <a href="/taxonomy/term/5809" title="">GM Crops</a>, <a href="/taxonomy/term/8604" title="">GMOs</a>, <a href="/taxonomy/term/6732" title="">Health</a>, <a href="/taxonomy/term/7313" title="">Health Effects</a>, <a href="/taxonomy/term/7502" title="">Herbicide</a>, <a href="/taxonomy/term/20777" title="">Latha Jishnu</a>, <a href="/taxonomy/term/20406" title="">Monsanto</a>, <a href="/taxonomy/term/13037" title="">Research</a>, <a href="/taxonomy/term/7578" title="">Toxicity Studies</a></div>
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<P><STRONG><BR>Michael Antoniou</STRONG>, head of the Nuclear Biology Group in the UK, has been studying the health effects of genetically modified (GM) crops since 1995. He hastens to add, however, that he does no research himself on the issue since his specialisation is human molecular genetics, a subject he teaches at King’s College London School of Medicine. In an interview to <STRONG>Latha Jishnu</STRONG>, he explains why the new research by Seralini et al on long-term toxicity of Monsanto’s Roundup herbicide and Roundup-tolerant GM maize has important pointers to human health risks</P></DIV><SPAN class=print-link></SPAN><br />
<DIV class=all-attached-images></DIV><br />
<P><STRONG><SPAN class=standalone-image style="WIDTH: 200px"><IMG title="Michael Antoniou" height=156 alt="Michael Antoniou" src="http://www.downtoearth.org.in/dte/userfiles/images/26(1).jpg" width=200 align=left border=0><SPAN class=caption>Michael Antoniou</SPAN></SPAN>What are the major takeaways from the research? </STRONG></P><br />
<P>It shows multiple impacts, most acutely in liver and kidney function and immune system disturbances. Most worrying is the extraordinarily large number of tumours developing earlier and more aggressively in the rats. I am shocked because it was so unexpected. </P><br />
<P><STRONG>But there have been other long-term studies. How significant is this study? </STRONG></P><br />
<P>This is unprecedented and very worrying because basically it proves that signs of toxicity in the short-term 90-day trials conducted by the industry actually escalate to serious liver and kidney damage, specially in male rats and lead to premature death. The Seralini study also expanded parameters and looked at something that Monsanto never did. It looked at sex-steroid hormones and also tried to tease out any toxic effects that could have occurred not just from GM maize but the combination of GM and Roundup.</P><br />
<P><STRONG>Any other changes? </STRONG></P><br />
<P>The Seralini lab also added a third feeding dose as per the OECD guidelines whereas Monsanto used only two. In fact, the French team followed the guidelines more scrupulously. </P><br />
<P><STRONG>Does it necessarily mean that it will affect human beings similarly? </STRONG></P><br />
<P><FONT color=#ee2222>It has major health implications not just for the animals which are fed the herbicide-tolerant GM maize (NK603) and the Roundup weedicide but also for human health.</FONT> The rat has always been used as a surrogate for human toxicity. All new pharmaceutical, agricultural and household substances are tested on rats before they are approved for use. This is the best indicator we can get of the likely impact of GM maize on human health. </P><br />
<P><STRONG>But regulators have never insisted even on the 90-day study and have ignored signs of toxicity in such trials. </STRONG></P><br />
<P>Yes, it is worrying that regulators have consistently dismissed the findings of the science of toxicity and not re-evaluated products that have been released in the market. The signs of toxicity in GM crops are very evident and industry and the regulators acknowledge it. But they invoke an incomprehensible concept of “biological insignificance” to dismiss such risks.</P><br />
<P><STRONG>The European regulator EFSA has already rejected the new research of Seralini as “of insufficient scientific quality to be considered as valid for risk assessment”. So what can be done? </STRONG></P><br />
<P>Earlier studies have also shown alarming health risks in animals. Independent scientists must continue to produce compelling research that will force a rethink.</P><br />
<DIV class="field field-type-userreference field-field-interviewee"><br />
<DIV class=field-label>Interviewee:&nbsp;</DIV><br />
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<DIV class="field-item odd">Michael Antoniou </DIV></DIV></DIV></DIV></DIV></p>
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		<title>[GMO] 세라리니 박사팀 연구결과에 대한 의 대응</title>
		<link>http://www.chsc.or.kr/?post_type=reference&#038;p=3546</link>
		<comments>http://www.chsc.or.kr/?post_type=reference&#038;p=3546#comments</comments>
		<pubDate>Sat, 13 Oct 2012 20:37:15 +0000</pubDate>
		<dc:creator>건강과대안</dc:creator>
				<category><![CDATA[GMO]]></category>
		<category><![CDATA[식품 · 의약품]]></category>
		<category><![CDATA[glyphosate]]></category>
		<category><![CDATA[GM Watch]]></category>
		<category><![CDATA[NK603]]></category>
		<category><![CDATA[글리포세이트]]></category>
		<category><![CDATA[라운드업]]></category>
		<category><![CDATA[세라리니]]></category>
		<category><![CDATA[안전성]]></category>
		<category><![CDATA[유전자조작 옥수수]]></category>
		<category><![CDATA[장기독성]]></category>
		<category><![CDATA[종양]]></category>

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		<description><![CDATA[세라리니 박사팀 연구결과에 대한 의 대응비판 1. 세라리니 박사팀의 실험은 국제적으로&#160;공인받은 실험방법을 사용하지 않았다&#160;&#8211;> [반박] 터무니 없는 음해다. 유전자조작(GM) 곡물이나 식품의 안전성을 검증하는 국제적으로 공인받은 실험방법 자체가 존재하지 [...]]]></description>
				<content:encoded><![CDATA[<p><P><FONT size=2>세라리니 박사팀 연구결과에 대한 <GM Watch>의 대응<BR><BR>비판 1. 세라리니 박사팀의 실험은 국제적으로&nbsp;공인받은 실험방법을 사용하지 않았다&nbsp;<BR><BR>&#8211;> [반박] 터무니 없는 음해다. 유전자조작(GM) 곡물이나 식품의 안전성을 검증하는 국제적으로 공인받은 실험방법 자체가 존재하지 않는다. 생명공학&nbsp;기업들과 정부 규제당국은 GM 안전성을 검증하는 공인된 실험방법을 수립하는 것을 반대해왔다. 그래서&nbsp;생명공학 기업들은 자신들의 GM 상품에 대해 자기 마음대로 안전성 실험을 설계해왔던 것이다. 심지어 생명공학 기업들은&nbsp;정부의 규제당국에 안전성 검사 서류를 제출할 때&nbsp;자신들에게 불리한 검사결과들을 &nbsp;제외시켜버리기까지 했다.<BR><BR>비판 2. 실험에 사용한 쥐의 샘플 수가 너무 적다 <BR>&#8211;> [반박]&nbsp; 몬산토가 90일 독성 실험에 사용한 쥐의 샘플도 200마리였다. 세라리니팀은 같은 샘플을 사용했다. 발암성 실험을 위해서는 더 많은 쥐를 샘플로 사용해야 하겠지만, 세라리니팀은 발암성 실험을 한 것이 아니라 독성실험을 수행한 것이다. 왜냐하면 몬산토사의 GM 옥수수가 종양이나 암을 일으킨다는 몬산토사 또는 독립 연구자들의 연구결과가 나온 바가 없기 때문에 발암성 시험을 할 이유가 없었다.<BR><BR>&#8211;> [세라리니팀의 답변 참조] 안전성 심사를 위해 몬산토에서 수행한 실험도 마찬가지로 200마리로 실험했을 뿐이다. 우리 연구에서는 쥐의 일생에 해당하는 2년 동안 장기&nbsp;실험을 했다. 몬산토는 겨우 90일 실험을&nbsp;했을 뿐이다. 독성학적으로도&nbsp;몬산토 실험보다 더 많은 항목들을 연구했다.&nbsp;&nbsp;더 많은 실험을 하기 위해서는 돈이 더 많이 든다. 이번 실험에 들어간 돈이 3200만 유로(약 460억원)나 들었다<BR><BR>비판 3. 세라리니&nbsp;실험은 대조군의&nbsp;수가 부족했다.<BR>&#8211;> [반박]&nbsp; 세라리니 연구팀의 실험은 실험군의 샘플 수(10마리)와 대조군의 샘플 수(10마리)가 똑같았으며, 이것은&nbsp;&nbsp;과학적 연구 관행과 부합한다. 참고용 대조군을 부적절하게 여분으로 더 설정하라고 권유하는 것은 훌륭한 과학적 연구 관행이라 볼 수 없다.&nbsp;그럴 경우 유전자 변형의 독성 효과를 은폐하게 되는 데이타 혼동(<FONT color=#454545> data &#8220;noise&#8221;)</FONT>만 초래할 것이다.<BR><BR>비판 4. 세라리니 실험은 종양에 자연적으로 잘 걸리는 타입의 쥐를 사용했다.<BR>&#8211;> [반박]&nbsp; 실험에 사용한 쥐(Sprague-Dawley)는 만산토사&nbsp;90일 동안의 GMO 독성 연구에도 사용되었으며, 생명공학 기업이나 독립적인 2년 만성독성 연구, 그리고 화학물질의 발암성 연구에 사용되었다. 통제된 실험에서 종양의 자연발생률은 문제가 되지 않는다. 문제는 GMO와 라운드업 농약을 투여한 실험군에서&nbsp;종양 발생이 증가하였다는 것이다. 세라리니팀의 연구에서는 모든 실험군이 암컷이나 수컷모두 큰 종양 발생률이 대조군에 비해 2-~3배 증가했다.<BR><BR>그러나 세라니니팀의 실험은 만성독성에 관한 것이지, 발암성 연구가 아니었다. 몬산토 사의 NK603 유전자조작 옥수수와 라운드업 제초제가 암을 불러일으키는 능력(발암성)이 있다는&nbsp;결론을 도출하기 위해서는 위해서는 2년 동안 실험군 및 성별 당 50마리의 쥐를 사용해야 한다.(세라리니팀은 10마리의 쥐를 사용했다.)&nbsp; 그럼에도 불구하고 종양성 실험결과(종양 발생 수의 증가, 더 어린 연령에 발병, 종양 크기가 더 커지는 공격성)이 NK603 유전자조작 옥수수와 라운드업 제초제를 투여한 실험군에서 눈에 뜨게 두드러지게 나타나기 때문에 대규모의 발암성 연구를 통해 추가 연구를 할 필요가 있다.<BR><BR>&#8211;> [세라리니팀의 답변 참조]&nbsp; 그렇다. 하지만 전 세계적으로 이 쥐(Sprague-Dawley)를 독성학 연구에 많이 사용하고 있다. 이 쥐는 생물학적으로 신체적으로 안정된 수준을 유지할 수 있는 장점이 있다. 게다가 이 쥐는 몬산토를 포함한 산업계가 GM 제품의 안전성을 평가하기 위해 처음 도입한 것이다. 중요한 것은 라운드업 제초제를 사용했건 사용하지 않았건 GM 옥수수를 급여한 쥐들이 질병에 더 빨리 걸렸다는 것이다.&#8221;</FONT><BR><BR>(계속)<BR><BR>GMWatch responds to criticisms of Seralini&#8217;s study</P><br />
<P class=articleinfo><SPAN class=createdate><FONT size=2>Thursday, 11 October 2012 15:49 </FONT></SPAN></P><br />
<P class=buttonheading>&nbsp;출처 : &nbsp;<A href="http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14305:gmwatch-responds-to-criticisms-of-seralinis-study">http://www.gmwatch.org/index.php?option=com_content&#038;view=article&#038;id=14305:gmwatch-responds-to-criticisms-of-seralinis-study</A><IMG alt="Attention: open in a new window." src="http://www.gmwatch.org/templates/beez/images/trans.gif"> <A title=Print _onclick="window.open(this.href,'win2','status=no,toolbar=no,scrollbars=yes,titlebar=no,menubar=no,resizable=yes,width=640,height=480,directories=no,location=no'); return false;" href="http://www.gmwatch.org/component/content/article/51-2012/14305-gmwatch-responds-to-criticisms-of-seralinis-study?tmpl=component&#038;print=1&#038;page=" rel=nofollow></A><A title=E-mail _onclick="window.open(this.href,'win2','width=400,height=350,menubar=yes,resizable=yes'); return false;" href="http://www.gmwatch.org/component/mailto/?tmpl=component&#038;link=d23794eb17624ec64f186c31fa05a681381aa7cc"></A></P><br />
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<P><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">We&#8217;ve compiled a list of the most common criticisms of Seralini&#8217;s <A href="http://www.sciencedirect.com/science/article/pii/S0278691512005637" target=_blank>study</A>, which found increased tumours, mortality, and organ damage in rats fed GM maize NK603 over a 2-year period and similar results in rats fed Roundup in tiny amounts, less than levels permitted in food, feed, and drinking water. Our answers follow.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">We&#8217;ll update this document as and when needed.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">1. Seralini&#8217;s experiments do not conform to internationally accepted protocols.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">No such protocols exist for GM food safety testing and industry and regulators have <A href="http://bit.ly/SHCfvm" target=_blank>opposed</A> attempts to establish them. So industry is free to design its own tests on its own products &#8211; or even to leave out inconvenient data from the dossier of tests it submits to regulators.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">2. Groups of rats (sample size) are too small.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Seralini used the same number of rats as Monsanto analysed for blood and urine chemistry in its <A href="http://www.sciencedirect.com/science/article/pii/S0278691504000547" target=_blank>90-day tests</A> on GM foods and the same number as is recommended in <A href="http://www.google.co.uk/url?sa=t&#038;rct=j&#038;q=&#038;esrc=s&#038;source=web&#038;cd=1&#038;cad=rja&#038;ved=0CCMQFjAA&#038;url=http%3A%2F%2Fwww.oecd.org%2Fdataoecd%2F55%2F19%2F41362977.pdf&#038;ei=3T94ULu1McO30QXnu4GgAw&#038;usg=AFQjCNF5Tbh0WxotwOR2_-85IqSoTiOsyA&#038;sig2=pb5XXRQXqQMcbRLqfrpxaQ" target=_blank>OECD chronic toxicity protocol</A> that Seralini mentioned in his paper. More rats are needed for a carcinogenicity study, but Seralini had no reason to embark on a carcinogenicity study, as no existing data from Monsanto or independent researchers indicated that NK603 GM maize or tiny amounts of Roundup might cause tumours or cancer.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">3. Seralini used an insufficient number of controls.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Seralini&#8217;s control groups were the same size as each treatment dose group, in line with standard scientific practice. It is not good scientific practice to introduce extra irrelevant &#8220;reference&#8221; control groups, though Monsanto has routinely done this in its <A href="http://www.sciencedirect.com/science/article/pii/S0278691504000547" target=_blank>tests</A> on GM foods. This practice only introduces data &#8220;noise&#8221; which hides any toxic effects of the genetic modification.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">4. Seralini used a type of rat naturally prone to tumours.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The Sprague-Dawley (SD) rat is the standard for Monsanto&#8217;s 90-day tests on GMOs and for industry and independent 2-year chronic toxicity and carcinogenicity tests on chemicals. The &#8220;spontaneous&#8221; rate of tumours does not matter in a controlled experiment &#8211; what matters is the increase in tumours in treatment groups. In Seralini&#8217;s study, all treatments in both sexes increased large tumour incidence by 2–3-fold in comparison to controls. </SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">However, Seralini&#8217;s study was for chronic toxicity, not carcinogenicity. In order to draw conclusions about the cancer-causing ability of NK603 GM maize and Roundup, proper carcinogenicity studies would have to be carried out with a 50 rats per sex per group (as compared with Seralini&#8217;s 10 rats per sex per group) over 2 years to test specifically for this effect. </SPAN>Nevertheless, the findings of tumours (increased number, lower age of onset, and greater aggressiveness) are so striking in the treatment groups that they demand further investigation through a full-scale <SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">carcinogenicity</SPAN> study.<BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">5. The fact that 30% of controls got tumours shows this rat is an unreliable model.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Control groups developed some tumours, but treated rats developed more. By the end of the study, 50-80% of female animals had developed tumours in all treated groups, with up to 3 tumors per animal, as against only 30% of controls. Peer-reviewed <A href="http://www.google.co.uk/url?sa=t&#038;rct=j&#038;q=&#038;esrc=s&#038;source=web&#038;cd=2&#038;cad=rja&#038;ved=0CCgQFjAB&#038;url=http%3A%2F%2Fwww.ramazzini.it%2Fricerca%2FpdfUpload%2FCancer%2520Medicine%252049-64_2006.pdf&#038;ei=ADt4UIf7AYP80QXak4FI&#038;usg=AFQjCNHW1elM5R8e_ebABFqC65V8c2yykA&#038;sig2=7Qeui3V_JKI_ynlV2Dus1g" target=_blank>data</A> show that the SD rat is an excellent human-equivalent model for predicting cancer in humans in long-term (2-year) studies: it gets around the same number of tumours as humans do over its lifespan. However, it must be remembered that Seralini&#8217;s study was not a carcinogenicity study, not because of the type of rat used, but because of the relatively few numbers of rats per group.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">6. SD rats get tumours when food intake is unrestricted.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The rats in Seralini&#8217;s study had unrestricted access to food and water, but so did the rats in Monsanto&#8217;s <A href="http://www.sciencedirect.com/science/article/pii/S0278691504000547" target=_blank>90-day studies</A> on GM foods, and so do most humans in real life, so this aspect of Seralini&#8217;s study reflects standard industry testing practices as well as realistic human exposures.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">7. The effects seen in Seralini&#8217;s study are within the historical norms for this type of rat.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">The only scientifically valid controls with which treatment groups of rats should be compared are the concurrent controls within the experiment. &#8220;Historical control data&#8221; drawn from a variety of sources should not be used, because in scientific experiments we only test one variable at a time. </SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">In Seralini&#8217;s experiment, the variables, each of which was tested separately, were exposure to NK603 maize, Roundup, and a combination of the two. This excludes the possibility that effects could be due to irrelevant factors such as different environmental conditions in which crops used in the diets were grown (which can produce differences in toxins or nutritional content). Industry studies on GMOs and chemicals often invoke historical control data to mask significant effects of harm found from exposure to the tested substance, but the practice is <A href="http://earthopensource.org/index.php/reports/why-monsantos-attempt-to-disappear-tumours-is-invalid" target=_blank>unscientific</A> and places public health at risk</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">8. No food intake data is presented, so we don&#8217;t know the dose of toxins ingested.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Seralini measured food intake more often than industry studies on GM foods and the absence of data in his published paper does not invalidate the findings observed.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">9. The outcomes including tumour incidence did not follow a linear dose response pattern (where the toxic effect increases as the dose increases). </SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Many toxins, especially those that affect the hormonal system, have nonlinear dose-response patterns – Roundup is one. Scientists have published papers about <A href="http://www.ncbi.nlm.nih.gov/pubmed/22419778" target=_blank>nonlinear dose-response patterns</A> since the 1990s, but industry and some risk assessment bodies cling to the outdated toxicological model of linear dose-response.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">10. Outcomes were sex-specific, e.g. the majority of tumours were found in females.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">Sex-specific toxic effects are well documented in the scientific literature, including in a <A href="http://www.ncbi.nlm.nih.gov/pubmed/17634926" target=_blank>study</A> on Roundup toxicity in rats and in <A href="http://www.enveurope.com/content/23/1/10" target=_blank>animal studies on GM foods</A>. The sex-specificity of certain toxic effects found in animal feeding trials on GM foods is routinely used by <A href="http://www.ncbi.nlm.nih.gov/pubmed/17900781" target=_blank>industry</A> and <A href="http://www.efsa.europa.eu/en/efsajournal/pub/19r.htm" target=_blank>EFSA</A> as an excuse to dismiss them, but this is scientifically unjustifiable, as sex-specific effects are to be expected when the hormonal system is involved.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">11. No mechanism for the effects observed has been established.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">There is no requirement in any regulatory system to establish mechanism of action for a toxin before regulatory action can be taken, and there is no burden of proof on scientists who find toxic effects to establish a mechanism before they report their findings. This is fortunate because it can take decades to establish mechanism, and sometimes a mechanism is never found.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">12. Seralini&#8217;s study is flawed and should be dismissed.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"><SPAN style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif">No study is perfect. But Seralini&#8217;s is far stronger, in terms of study length, parameters examined, and carefulness of design (which enabled distinction between effects of the genetic modification and the herbicide it is grown with), than the 90-day studies carried out by industry for regulatory approval of GM foods.</SPAN><BR style="FONT-SIZE: 13px; COLOR: #454545; LINE-HEIGHT: normal; FONT-FAMILY: arial, helvetica, sans-serif"></P></DIV></p>
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